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Transcriptional regulation of long-term memory in the marine snail Aplysia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Bailey, Craig H | - |
dc.contributor.author | Kandel, Eric R | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2017-03-17T07:43:26Z | - |
dc.date.available | 2017-03-17T17:19:23Z | - |
dc.date.issued | 2008-06-17 | - |
dc.identifier.citation | Molecular Brain, 1(1):3 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109816 | - |
dc.description.abstract | Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new protein synthesis. On the cellular level, transcriptional regulation is thought to be the starting point for a series of molecular steps necessary for both the initiation and maintenance of long-term synaptic facilitation (LTF). The core molecular features of transcriptional regulation involved in the long-term process are evolutionally conserved in Aplysia, Drosophila, and mouse, and indicate that gene regulation by the c yclic AMP r esponse e lement b inding protein (CREB) acting in conjunction with different combinations of transcriptional factors is critical for the expression of many forms of long-term memory. In the marine snail Aplysia, the molecular mechanisms that underlie the storage of long-term memory have been extensively studied in the monosynaptic connections between identified sensory neuron and motor neurons of the gill-withdrawal reflex. One tail shock or one pulse of serotonin (5-HT), a modulatory transmitter released by tail shocks, produces a transient facilitation mediated by the cAMP-dependent protein kinase leading to covalent modifications in the sensory neurons that results in an enhancement of transmitter release and a strengthening of synaptic connections lasting minutes. By contrast, repeated pulses of 5-hydroxytryptamine (5-HT) induce a transcription- and translation-dependent long-term facilitation (LTF) lasting more than 24 h and trigger the activation of a family of transcription factors in the presynaptic sensory neurons including ApCREB1, ApCREB2 and ApC/EBP. In addition, we have recently identified novel transcription factors that modulate the expression of ApC/EBP and also are critically involved in LTF. In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Transcriptional regulation of long-term memory in the marine snail Aplysia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이용석 | - |
dc.contributor.AlternativeAuthor | 강봉균 | - |
dc.identifier.doi | 10.1186/1756-6606-1-3 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Lee et al; licensee BioMed Central Ltd. | - |
dc.date.updated | 2017-01-06T10:34:36Z | - |
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