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Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients

Cited 10 time in Web of Science Cited 10 time in Scopus
Authors
Lim, Chae-Seok; Yang, Jung-eun; Lee, You-Kyung; Lee, Kyungmin; Lee, Jin-A; Kaang, Bong-Kiun
Issue Date
2015-09-30
Publisher
BioMed Central
Citation
Molecular Brain, 8(1):57
Keywords
Autism spectrum disorder (ASD)Cellular reprogrammingInduced pluripotent stem cells (iPSCs)Neural differentiation
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social cognition, language development, and repetitive/restricted behaviors. Due to the complexity and heterogeneity of ASD and lack of a proper human cellular model system, the pathophysiological mechanism of ASD during the developmental process is largely unknown. However, recent progress in induced pluripotent stem cell (iPSC) technology as well as in vitro neural differentiation techniques have allowed us to functionally characterize neurons and analyze cortical development during neural differentiation. These technical advances will increase our understanding of the pathogenic mechanisms of heterogeneous ASD and help identify molecular biomarkers for patient stratification as well as personalized medicine. In this review, we summarize our current knowledge of iPSC generation, differentiation of specific neuronal subtypes from iPSCs, and phenotypic characterizations of human ASD patient-derived iPSC models. Finally, we discuss the current limitations of iPSC technology and future directions of ASD pathophysiology studies using iPSCs.
Language
English
URI
https://hdl.handle.net/10371/109820
DOI
https://doi.org/10.1186/s13041-015-0146-6
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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