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Impaired learning and memory in CD38 null mutant mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Somi | - |
dc.contributor.author | Kim, TaeHyun | - |
dc.contributor.author | Lee, Hye-Ryeon | - |
dc.contributor.author | Jang, Eun-Hye | - |
dc.contributor.author | Ryu, Hyun-Hee | - |
dc.contributor.author | Kang, Minkyung | - |
dc.contributor.author | Rah, So-Young | - |
dc.contributor.author | Yoo, Juyoun | - |
dc.contributor.author | Lee, Bolam | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Lim, Chae Seok | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Kim, Uh-Hyun | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2017-03-17T08:03:02Z | - |
dc.date.available | 2017-03-17T17:26:41Z | - |
dc.date.issued | 2016-02-09 | - |
dc.identifier.citation | Molecular Brain, 9(1):16 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109823 | - |
dc.description.abstract | CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38 knockout (CD38−/−) mice display ASD-like behavioral phenotypes including deficient parental behavior and poor social recognition memory. Although ASD and learning deficits commonly co-occur, the role of CD38 in learning and memory has not been investigated. We report that CD38−/− mice show deficits in various learning and memory tasks such as the Morris water maze, contextual fear conditioning, and the object recognition test. However, either long-term potentiation or long-term depression is not impaired in the hippocampus of CD38−/− mice. Our results provide convincing evidence that CD38−/− mice show deficits in various learning and memory tasks including spatial and non-spatial memory tasks. Our data demonstrate that CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Impaired learning and memory in CD38 null mutant mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김소미 | - |
dc.contributor.AlternativeAuthor | 김태현 | - |
dc.contributor.AlternativeAuthor | 이혜련 | - |
dc.contributor.AlternativeAuthor | 장은혜 | - |
dc.contributor.AlternativeAuthor | 류현희 | - |
dc.contributor.AlternativeAuthor | 강민경 | - |
dc.contributor.AlternativeAuthor | 라소영 | - |
dc.contributor.AlternativeAuthor | 유주연 | - |
dc.contributor.AlternativeAuthor | 이보람 | - |
dc.contributor.AlternativeAuthor | 김재익 | - |
dc.contributor.AlternativeAuthor | 임채석 | - |
dc.contributor.AlternativeAuthor | 김상정 | - |
dc.contributor.AlternativeAuthor | 김어현 | - |
dc.contributor.AlternativeAuthor | 이용석 | - |
dc.contributor.AlternativeAuthor | 강봉균 | - |
dc.identifier.doi | 10.1186/s13041-016-0195-5 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Kim et al. | - |
dc.date.updated | 2017-01-06T10:35:58Z | - |
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