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Impaired learning and memory in CD38 null mutant mice

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dc.contributor.authorKim, Somi-
dc.contributor.authorKim, TaeHyun-
dc.contributor.authorLee, Hye-Ryeon-
dc.contributor.authorJang, Eun-Hye-
dc.contributor.authorRyu, Hyun-Hee-
dc.contributor.authorKang, Minkyung-
dc.contributor.authorRah, So-Young-
dc.contributor.authorYoo, Juyoun-
dc.contributor.authorLee, Bolam-
dc.contributor.authorKim, Jae-Ick-
dc.contributor.authorLim, Chae Seok-
dc.contributor.authorKim, Sang Jeong-
dc.contributor.authorKim, Uh-Hyun-
dc.contributor.authorLee, Yong-Seok-
dc.contributor.authorKaang, Bong-Kiun-
dc.date.accessioned2017-03-17T08:03:02Z-
dc.date.available2017-03-17T17:26:41Z-
dc.date.issued2016-02-09-
dc.identifier.citationMolecular Brain, 9(1):16ko_KR
dc.identifier.urihttp://hdl.handle.net/10371/109823-
dc.description.abstractCD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38 knockout (CD38−/−) mice display ASD-like behavioral phenotypes including deficient parental behavior and poor social recognition memory. Although ASD and learning deficits commonly co-occur, the role of CD38 in learning and memory has not been investigated. We report that CD38−/− mice show deficits in various learning and memory tasks such as the Morris water maze, contextual fear conditioning, and the object recognition test. However, either long-term potentiation or long-term depression is not impaired in the hippocampus of CD38−/− mice. Our results provide convincing evidence that CD38−/− mice show deficits in various learning and memory tasks including spatial and non-spatial memory tasks. Our data demonstrate that CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.titleImpaired learning and memory in CD38 null mutant miceko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김소미-
dc.contributor.AlternativeAuthor김태현-
dc.contributor.AlternativeAuthor이혜련-
dc.contributor.AlternativeAuthor장은혜-
dc.contributor.AlternativeAuthor류현희-
dc.contributor.AlternativeAuthor강민경-
dc.contributor.AlternativeAuthor라소영-
dc.contributor.AlternativeAuthor유주연-
dc.contributor.AlternativeAuthor이보람-
dc.contributor.AlternativeAuthor김재익-
dc.contributor.AlternativeAuthor임채석-
dc.contributor.AlternativeAuthor김상정-
dc.contributor.AlternativeAuthor김어현-
dc.contributor.AlternativeAuthor이용석-
dc.contributor.AlternativeAuthor강봉균-
dc.identifier.doi10.1186/s13041-016-0195-5-
dc.language.rfc3066en-
dc.rights.holderKim et al.-
dc.date.updated2017-01-06T10:35:58Z-
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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