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Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Hyunjung | - |
dc.contributor.author | Jang, Yong Ho | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Yu, Seong-Woon | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.date.accessioned | 2017-03-17T08:10:56Z | - |
dc.date.available | 2017-03-17T17:50:18Z | - |
dc.date.issued | 2016-04-19 | - |
dc.identifier.citation | Molecular Brain, 9(1):42 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109825 | - |
dc.description.abstract | Background
Intracerebral hemorrhage (ICH) is one of the major causes of stroke. After onset of ICH, massive infiltration of macrophages is detected in the peri-hematoma regions. Still, the function of these macrophages in ICH has not been completely elucidated. Results In a collagenase-induced ICH model, CX3CR1+ macrophages accumulated in the peri-hematoma region. Characterization of these macrophages revealed expression of alternatively activated (M2) macrophage markers. In the macrophage-depleted mice, ICH-induced brain lesion volume was larger and neurological deficits were more severe compared to those of control mice, indicating a protective role of these macrophages in ICH. In the ICH-injured brain, mannose receptor-expressing macrophages increased at a delayed time point after ICH, indicating M2 polarization of the brain-infiltrating macrophages in the brain microenvironment. To explore this possibility, bone marrow-derived macrophages (BMDM) were co-cultured with mouse brain glial cells and then tested for activation phenotype. Upon co-culture with glia, the number of mannose receptor-positive M2 macrophages was significantly increased. Furthermore, treatment with glia-conditioned media increased the number of BMDM of M2 phenotype. Conclusions In this study, our data suggest that brain-infiltrating macrophages after ICH are polarized to the M2 phenotype by brain glial cells and thereby contribute to recovery from ICH injury. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Immune response | ko_KR |
dc.subject | Macrophages | ko_KR |
dc.subject | Wound healing | ko_KR |
dc.title | Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 민현정 | - |
dc.contributor.AlternativeAuthor | 장용호 | - |
dc.contributor.AlternativeAuthor | 조익현 | - |
dc.contributor.AlternativeAuthor | 유성운 | - |
dc.contributor.AlternativeAuthor | 이성중 | - |
dc.identifier.doi | 10.1186/s13041-016-0225-3 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Min et al. | - |
dc.date.updated | 2017-01-06T10:36:14Z | - |
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