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Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study

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dc.contributor.authorYoon, Chang-Yun-
dc.contributor.authorKim, Yung Ly-
dc.contributor.authorHan, Seung Hyeok-
dc.contributor.authorYoo, Tae-Hyun-
dc.contributor.authorSung, Su-Ah-
dc.contributor.authorChung, Woo-kyung-
dc.contributor.authorChae, Dong-Wan-
dc.contributor.authorKim, Yong-Soo-
dc.contributor.authorAhn, Curie-
dc.contributor.authorChoi, Kyu Hun-
dc.date.accessioned2017-03-21T00:17:47Z-
dc.date.available2017-03-21T09:25:36Z-
dc.date.issued2016-11-14-
dc.identifier.citationDiabetology & Metabolic Syndrome, 8(1):75ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/109885-
dc.description.abstractBackground
In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease.

Methods
The KoreaN Cohort Study for Outcome in Patients with Chronic Kidney Disease is a cohort study that enrolled subjects with chronic kidney disease throughout South Korea. From February 2011 to July 2014, data were collected from 1332 patients with chronic kidney disease.

Results
The mean age of the patients was 53.5 years and 803 patients (60.7%) were men. The median adiponectin level was 10.7 μg/mL and 585 (44.3%) patients had metabolic syndrome. In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β = 0.006), whereas it was negatively associated with serum albumin (β = −0.284), triglyceride (log β = −0.288), high sensitivity C-reactive protein (log β = −0.058) levels and estimated glomerular filtration rate (β = −0.005). Multiple logistic regression analysis indicated that low adiponectin level was independently associated with a higher risk of metabolic syndrome (per 1 μg/mL increase; odds ratio = 0.953, 95% confidence interval = 0.898–0.970, P < 0.001) after adjustment for multiple confounding factors.

Conclusions
Hypoadiponectinemia is independently associated with the presence of metabolic syndrome in patients with chronic kidney disease.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectAdiponectinko_KR
dc.subjectChronic kidney diseaseko_KR
dc.subjectMetabolic syndromeko_KR
dc.titleHypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor윤창윤-
dc.contributor.AlternativeAuthor김영리-
dc.contributor.AlternativeAuthor한승혁-
dc.contributor.AlternativeAuthor유태현-
dc.contributor.AlternativeAuthor성수아-
dc.contributor.AlternativeAuthor정우경-
dc.contributor.AlternativeAuthor채동완-
dc.contributor.AlternativeAuthor김용수-
dc.contributor.AlternativeAuthor안규리-
dc.contributor.AlternativeAuthor최규훈-
dc.identifier.doi10.1186/s13098-016-0191-z-
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2017-01-06T10:44:57Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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