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Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Chang-Yun | - |
dc.contributor.author | Kim, Yung Ly | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Sung, Su-Ah | - |
dc.contributor.author | Chung, Woo-kyung | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Kim, Yong-Soo | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Choi, Kyu Hun | - |
dc.date.accessioned | 2017-03-21T00:17:47Z | - |
dc.date.available | 2017-03-21T09:25:36Z | - |
dc.date.issued | 2016-11-14 | - |
dc.identifier.citation | Diabetology & Metabolic Syndrome, 8(1):75 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109885 | - |
dc.description.abstract | Background
In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. Methods The KoreaN Cohort Study for Outcome in Patients with Chronic Kidney Disease is a cohort study that enrolled subjects with chronic kidney disease throughout South Korea. From February 2011 to July 2014, data were collected from 1332 patients with chronic kidney disease. Results The mean age of the patients was 53.5years and 803 patients (60.7%) were men. The median adiponectin level was 10.7μg/mL and 585 (44.3%) patients had metabolic syndrome. In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β=0.006), whereas it was negatively associated with serum albumin (β=−0.284), triglyceride (log β=−0.288), high sensitivity C-reactive protein (log β=−0.058) levels and estimated glomerular filtration rate (β=−0.005). Multiple logistic regression analysis indicated that low adiponectin level was independently associated with a higher risk of metabolic syndrome (per 1μg/mL increase; odds ratio=0.953, 95% confidence interval=0.898–0.970, P<0.001) after adjustment for multiple confounding factors. Conclusions Hypoadiponectinemia is independently associated with the presence of metabolic syndrome in patients with chronic kidney disease. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Adiponectin | ko_KR |
dc.subject | Chronic kidney disease | ko_KR |
dc.subject | Metabolic syndrome | ko_KR |
dc.title | Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤창윤 | - |
dc.contributor.AlternativeAuthor | 김영리 | - |
dc.contributor.AlternativeAuthor | 한승혁 | - |
dc.contributor.AlternativeAuthor | 유태현 | - |
dc.contributor.AlternativeAuthor | 성수아 | - |
dc.contributor.AlternativeAuthor | 정우경 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.contributor.AlternativeAuthor | 김용수 | - |
dc.contributor.AlternativeAuthor | 안규리 | - |
dc.contributor.AlternativeAuthor | 최규훈 | - |
dc.identifier.doi | 10.1186/s13098-016-0191-z | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2017-01-06T10:44:57Z | - |
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