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Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Chang, Soog-Hee | - |
dc.contributor.author | Kim, In Je | - |
dc.contributor.author | Lipsky, Peter E. | - |
dc.contributor.author | Lee, Jisoo | - |
dc.date.accessioned | 2017-03-21T04:26:20Z | - |
dc.date.available | 2017-03-21T13:45:19Z | - |
dc.date.issued | 2015-07-25 | - |
dc.identifier.citation | Arthritis Research & Therapy, 17(1):190 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109902 | - |
dc.description.abstract | Introduction
Pre-naïve B cells represent an intermediate stage in human B-cell development with some functions of mature cells, but their involvement in immune responses is unknown. The aim of this study was to determine the functional role of normal pre-naïve B cells during immune responses and possible abnormalities in systemic lupus erythematosus (SLE) that might contribute to disease pathogenesis. Methods Pre-naïve, naïve, and memory B cells from healthy individuals and SLE patients were stimulated through CD40 and were analyzed for interleukin-10 (IL-10) production and co-stimulatory molecule expression and their regulation of T-cell activation. Autoreactivity of antibodies produced by pre-naïve B cells was tested by measuring immunoglobulin M (IgM) autoantibodies in culture supernatants after differentiation. Results CD40-stimulated pre-naïve B cells produce larger amounts of IL-10 but did not suppress CD4+ T-cell cytokine production. Activated pre-naïve B cells demonstrated IL-10-mediated ineffective promotion of CD4+ T-cell proliferation and induction of CD4+FoxP3+ T cells and IL-10 independent impairment of co-stimulatory molecule expression and tumor necrosis factor-alpha (TNF-α) and IL-6 production. IgM antibodies produced by differentiated pre-naïve B cells were reactive to single-stranded deoxyribonucleic acid. SLE pre-naïve B cells were defective in producing IL-10, and co-stimulatory molecule expression was enhanced, resulting in promotion of robust CD4+ T-cell proliferation. Conclusions There is an inherent and IL-10-mediated mechanism that limits the capacity of normal pre-naïve B cells from participating in cellular immune response, but these cells can differentiate into autoantibody-secreting plasma cells. In SLE, defects in IL-10 secretion permit pre-naïve B cells to promote CD4+ T-cell activation and may thereby enhance the development of autoimmunity. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 심지현 | - |
dc.contributor.AlternativeAuthor | 김항래 | - |
dc.contributor.AlternativeAuthor | 장숙희 | - |
dc.contributor.AlternativeAuthor | 김인제 | - |
dc.contributor.AlternativeAuthor | 이지수 | - |
dc.identifier.doi | 10.1186/s13075-015-0687-1 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Sim et al. | - |
dc.date.updated | 2017-01-06T10:47:30Z | - |
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