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Application of structural equation models to construct genetic networks using differentially expressed genes and single-nucleotide polymorphisms

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dc.contributor.authorLee, Seungmook-
dc.contributor.authorJhun, Mina-
dc.contributor.authorLee, Eun-Kyung-
dc.contributor.authorPark, Taesung-
dc.date.accessioned2017-03-27T01:04:13Z-
dc.date.available2017-03-27T10:08:59Z-
dc.date.issued2007-12-18-
dc.identifier.citationBMC Proceedings, 1(Suppl 1):S76ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/109992-
dc.description.abstractUnderstanding the genetic basis of human variation is an important goal of biomedical research. In this study, we used structural equation models (SEMs) to construct genetic networks to model how specific single-nucleotide polymorphisms (SNPs) from two genes known to cause acute myeloid leukemia (AML) by somatic mutation, runt-related transcription factor 1 (RUNX1) and ets variant gene 6 (ETV6), affect expression levels of other genes and how RUNX1 and ETV6 are related to each other. The SEM approach allows us to compare several candidate models from which an explanatory genetic network can be constructed.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.titleApplication of structural equation models to construct genetic networks using differentially expressed genes and single-nucleotide polymorphismsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이승묵-
dc.contributor.AlternativeAuthor전미나-
dc.contributor.AlternativeAuthor이은경-
dc.contributor.AlternativeAuthor박태성-
dc.identifier.doi10.1186/1753-6561-1-S1-S76-
dc.language.rfc3066en-
dc.rights.holderLee et al; licensee BioMed Central Ltd.-
dc.date.updated2017-01-06T10:52:48Z-
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Statistics (통계학과)Journal Papers (저널논문_통계학과)
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