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Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Chi-Hyun | - |
dc.contributor.author | Lee, Min Jung | - |
dc.contributor.author | Kim, Jong-Pyung | - |
dc.contributor.author | Yoo, Ick Dong | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.date.accessioned | 2009-11-03T02:50:54Z | - |
dc.date.available | 2009-11-03T02:50:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Photochem. Photobiol. 82, 574-578 | en |
dc.identifier.issn | 0031-8655 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16613515 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11044 | - |
dc.description.abstract | Repetitive exposure of the skin to UV radiation induces various harmful changes, such as thickening, wrinkle formation, inflammation and carcinogenesis. A variety of natural compounds and synthetic compounds have been studied to determine whether they can prevent UV-induced harmful effects. In this study, we investigated the effect of a novel compound, Melanocin A, which was isolated from Eupenicillium shearii F80695, on UV-induced premature skin aging. First, we studied the effect of Melanocin A on UV-induced matrix metalloproteinase (MMP)-9 expression in an immortalized human keratinocyte cell line, HaCaT, in vitro. Acute UV irradiation induced MMP-9 expression at both the mRNA and protein levels and Melanocin A suppressed this expression in a dose-dependent manner. We then investigated the effect of Melanocin A on UV-induced skin changes in hairless mice in vivo. Chronic exposure of hairless mouse dorsal skin to UV increased skin thickness and induced wrinkle formation and the gelatinase activities of MMP-2 and MMP-9. Moreover, Melanocin A significantly suppressed UV-induced morphologic skin changes and MMP-2 and MMP-9 expression. Taken together, these results show that Melanocin A can prevent the harmful effects of UV that lead to skin aging. Therefore, we suggest that Melanocin A should be viewed as a potential therapeutic agent for preventing and/or treating premature skin aging. | en |
dc.language.iso | en | en |
dc.publisher | Blackwell Publishing | en |
dc.subject | Cell Line | en |
dc.subject | Cyanides/*pharmacology | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Eurotiales/*chemistry | en |
dc.subject | Keratinocytes/cytology/*drug effects/physiology | en |
dc.subject | Matrix Metalloproteinase 2/genetics/metabolism | en |
dc.subject | Matrix Metalloproteinase 9/genetics/metabolism | en |
dc.subject | Mice, Hairless | en |
dc.subject | Phototherapy/methods | en |
dc.subject | Proteins/analysis/metabolism | en |
dc.subject | RNA, Messenger/analysis/metabolism | en |
dc.subject | Skin Aging/*drug effects/physiology/radiation effects | en |
dc.subject | Time Factors | en |
dc.subject | Ultraviolet Rays/*adverse effects | en |
dc.title | Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 이민정 | - |
dc.contributor.AlternativeAuthor | 이민정 | - |
dc.contributor.AlternativeAuthor | 김종평 | - |
dc.contributor.AlternativeAuthor | 김종평 | - |
dc.contributor.AlternativeAuthor | 유익동 | - |
dc.contributor.AlternativeAuthor | 유익동 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1562/2005-07-26-RA-623 | - |
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