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Reduced potency after refrigerated storage of botulitum toxin A: human extensor digitorum brevis muscle study

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dc.contributor.authorPaik, Nam-Jong-
dc.contributor.authorSeo, Kyle-
dc.contributor.authorEun, Hee Chul-
dc.date.accessioned2009-11-03T02:53:38Z-
dc.date.available2009-11-03T02:53:38Z-
dc.date.issued2006-
dc.identifier.citationMov Disord 2006;21:1759-1763en
dc.identifier.issn0885-3185 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16856132-
dc.identifier.urihttps://hdl.handle.net/10371/11046-
dc.description.abstractTo determine whether the potency of botulinum toxin A (BTA) decreases after being reconstituted with normal saline and stored in refrigerator, we injected one side of the extensor digitorum brevis muscle with 2.5 units of botulinum toxin A that had been immediately reconstituted with saline, and the contralateral side with identical material that had been reconstituted and stored in a refrigerator for preselected periods (1, 2, and 4 weeks) in 32 healthy volunteers. Mean compound muscle action potential amplitudes expressed as a percentage of the baseline amplitude were more reduced in sides injected with immediately reconstituted BTA than in sides injected with BTA stored for 1 week or more (P < 0.05). No bacterial growth was observed in any stored BTA samples. Storage of reconstituted BTA at low temperatures may affect the potency of the toxin. Therefore, the use of BTA after refrigerated storage is not recommended.en
dc.language.isoenen
dc.publisherJohn Wiley & Sonsen
dc.subjectbotulinum toxinen
dc.subjectpotencyen
dc.subjectstorageen
dc.subjectEreconstitutionen
dc.titleReduced potency after refrigerated storage of botulitum toxin A: human extensor digitorum brevis muscle studyen
dc.typeArticleen
dc.contributor.AlternativeAuthor백남종-
dc.contributor.AlternativeAuthor은희철-
dc.identifier.doi10.1002/mds.21044-
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