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Reduced potency after refrigerated storage of botulitum toxin A: human extensor digitorum brevis muscle study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paik, Nam-Jong | - |
dc.contributor.author | Seo, Kyle | - |
dc.contributor.author | Eun, Hee Chul | - |
dc.date.accessioned | 2009-11-03T02:53:38Z | - |
dc.date.available | 2009-11-03T02:53:38Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Mov Disord 2006;21:1759-1763 | en |
dc.identifier.issn | 0885-3185 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16856132 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11046 | - |
dc.description.abstract | To determine whether the potency of botulinum toxin A (BTA) decreases after being reconstituted with normal saline and stored in refrigerator, we injected one side of the extensor digitorum brevis muscle with 2.5 units of botulinum toxin A that had been immediately reconstituted with saline, and the contralateral side with identical material that had been reconstituted and stored in a refrigerator for preselected periods (1, 2, and 4 weeks) in 32 healthy volunteers. Mean compound muscle action potential amplitudes expressed as a percentage of the baseline amplitude were more reduced in sides injected with immediately reconstituted BTA than in sides injected with BTA stored for 1 week or more (P < 0.05). No bacterial growth was observed in any stored BTA samples. Storage of reconstituted BTA at low temperatures may affect the potency of the toxin. Therefore, the use of BTA after refrigerated storage is not recommended. | en |
dc.language.iso | en | en |
dc.publisher | John Wiley & Sons | en |
dc.subject | botulinum toxin | en |
dc.subject | potency | en |
dc.subject | storage | en |
dc.subject | Ereconstitution | en |
dc.title | Reduced potency after refrigerated storage of botulitum toxin A: human extensor digitorum brevis muscle study | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 백남종 | - |
dc.contributor.AlternativeAuthor | 은희철 | - |
dc.identifier.doi | 10.1002/mds.21044 | - |
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