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Risk factors for local tumor recurrence after segmental transarterial chemoembolization for hepatocellular carcinoma: the importance of tumor located in the segmental border zone

Cited 7 time in Web of Science Cited 6 time in Scopus
Authors
Cho, Yun Ku; Chung, Jin Wook; Ahn, Yong-Sik; Park, Yoon-Ok; Kim, Jae Kyun; Byun, Jong-Hoon
Issue Date
2006
Publisher
The Korean Radiological Society
Citation
Korean J Radiol 2006;7:267-274
Keywords
Liver neoplasmstherapy chemoembolizationCarcinoma, Hepatocellular/*pathology/*therapy*Chemoembolization, TherapeuticChi-Square DistributionDoxorubicin/administration & dosageIodized Oil/administration & dosageNeoplasm Recurrence, LocalProportional Hazards ModelsRetrospective Studies
Abstract
OBJECTIVE: We wanted to evaluate whether tumors located in a segmental border zone are predisposed to local recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma. MATERIALS AND METHODS: Seventy-three hepatocellular carcinoma nodules were retrospectively analyzed for local tumor recurrence after performing segmental transarterial chemoembolization by using follow-up CT studies (median follow-up period: 20 months, range: 4-77 months). The tumors were divided into two groups according to whether the lesions were located at the segmental border zone (Group I) or not (Group II). Comparison of the tumor characteristics and chemoembolization methods between the two groups was performed using the chi-square test. The local recurrence rates were compared by Kaplan-Meyer method and analyzed with the log rank test. RESULT: Local tumor recurrence occurred for 25 hepatocellular carcinoma nodules (42.9%). The follow-up periods, tumor characteristics and chemoembolization methods between Groups l and ll were comparable. The local recurrence rate was 64.0% (16/25) in Group I and 18.8% (9/48) in Group II. The difference was statistically significant on the univariate and multivariate analyses (p = 0.000 for both). CONCLUSION: Tumor location in a segmental border zone was a significant risk factor for local tumor recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma.
ISSN
1229-6929 (Print)
2005-8330 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17143030

https://hdl.handle.net/10371/11062
DOI
https://doi.org/10.3348/kjr.2006.7.4.267
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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