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Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Kim, Se-Jeong | - |
dc.contributor.author | Sinn, Dong-In | - |
dc.contributor.author | Kim, Seung U. | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Roh, Jae-Kyu | - |
dc.date.accessioned | 2009-11-04T04:13:28Z | - |
dc.date.available | 2009-11-04T04:13:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Brain Res. 1073-1074, 190-201 | en |
dc.identifier.issn | 0006-8993 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4J2TSRB-9&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fc1cd00aeeb342a383d5fa2a1a7434a5 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16423324 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11093 | - |
dc.description.abstract | The adult brain harbors multipotent stem cells, which reside in specialized niches that support self-renewal. Granulocyte colony-stimulating factor (G-CSF) induces bone marrow stem cells proliferation and mobilization from their niche, and activates endothelial cell proliferation, which might help to establish a vascular niche for neural stem cells (NSCs). Here, we show that G-CSF induced receptor-mediated proliferation and differentiation of neural precursors in human NSCs cultures and in adult rat brain in vivo. In human NSCs cultures, G-CSF activated STAT3 and 5, and increased VEGF and its receptor, VEGFR2 (Flk-1) expression, and VEGFR2 tyrosine kinase inhibitor blocked the neurogenesis stimulated by G-CSF. G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Granulocyte colony-stimulating | en |
dc.subject | factor (G-CSF) | en |
dc.subject | Neurogenesis | en |
dc.subject | G-CSFR | en |
dc.subject | STAT | en |
dc.subject | VEGF | en |
dc.title | Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 김세정 | - |
dc.contributor.AlternativeAuthor | 신동인 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.identifier.doi | 10.1016/j.brainres.2005.12.037 | - |
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