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Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury

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dc.contributor.authorJung, Keun-Hwa-
dc.contributor.authorChu, Kon-
dc.contributor.authorKo, Song-Yi-
dc.contributor.authorLee, Soon-Tae-
dc.contributor.authorSinn, Dong-In-
dc.contributor.authorPark, Dong-Kyu-
dc.contributor.authorKim, Jeong-Min-
dc.contributor.authorSong, Eun-Cheol-
dc.contributor.authorKim, Manho-
dc.contributor.authorRoh, Jae-Kyu-
dc.date.accessioned2009-11-04T04:42:19Z-
dc.date.available2009-11-04T04:42:19Z-
dc.date.issued2006-
dc.identifier.citationStroke. 2006;37:2744-2750en
dc.identifier.issn1524-4628 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17008610-
dc.identifier.urihttps://hdl.handle.net/10371/11100-
dc.description.abstractBACKGROUND AND PURPOSE: The rate of nitric oxide (NO) generation from nitrite is linearly dependent on reductions in oxygen and pH levels. Recently, nitrite-derived NO has been reported to exert a profound protection against liver and heart ischemia-reperfusion injury. In this study, we hypothesized that nitrite would be reduced to NO in the ischemic brain and exert NO-dependent neuroprotective effects. METHODS: Cerebral ischemia-reperfusion injury was induced by intraluminal thread occlusion of middle cerebral artery in the adult male rats. Solutions of sodium nitrite were infused intravenously at the time of reperfusion. Sodium nitrate and carboxy-PTIO (30 minutes before ischemic surgery), a direct NO scavenger, were infused for comparisons. RESULTS: Nitrite reduced infarction volume and enhanced local cerebral blood flow and functional recovery. The effects were observed at concentrations of 48 nmol and 480 nmol, but not at 4800 nmol nitrite and 480 nmol nitrate. The neuroprotective effects of nitrite were inhibited completely by the carboxy-PTIO. The 480 nmol nitrite attenuated dihydroethidium activity, 3-nitrotyrosine formation, and lipid peroxidation in the ischemic brain. CONCLUSIONS: Nitrite exerted profound neuroprotective effects with antioxidant properties in the ischemic brains. These results suggest that nitrite, as a biological storage reserve of NO, may be a novel therapeutic agent in the setting of acute stroke.en
dc.description.sponsorshipThis study was supported by a Korean Research Foundation grant
funded by the Korean Government (MOEHRD, Basic Research
Promotion Fund, KRF-2005-015-E00182).
en
dc.language.isoen-
dc.publisherAmerican Heart Associationen
dc.subjectcerebral ischemia-reperfusion injuryen
dc.subjectneuroprotectionen
dc.subjectnitric oxideen
dc.subjectnitriteen
dc.subjectoxidative stressen
dc.titleEarly intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injuryen
dc.typeArticleen
dc.contributor.AlternativeAuthor정근화-
dc.contributor.AlternativeAuthor주건-
dc.contributor.AlternativeAuthor고송이-
dc.contributor.AlternativeAuthor이순태-
dc.contributor.AlternativeAuthor신동인-
dc.contributor.AlternativeAuthor박동규-
dc.contributor.AlternativeAuthor김정민-
dc.contributor.AlternativeAuthor송은철-
dc.contributor.AlternativeAuthor김만호-
dc.contributor.AlternativeAuthor노재규-
dc.identifier.doi10.1161/01.STR.0000245116.40163.1c-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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