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Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sinn, Dong-In | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Song, Eun-Cheol | - |
dc.contributor.author | Kim, Jeong-Min | - |
dc.contributor.author | Park, Dong-Kyu | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Roh, Jae-Kyu | - |
dc.date.accessioned | 2009-11-04T05:31:00Z | - |
dc.date.available | 2009-11-04T05:31:00Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Neurosci Lett. 411 (2007) 238-242 | en |
dc.identifier.issn | 0304-3940 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17123715 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11114 | - |
dc.description.abstract | Memantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits hematoma expansion and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces perihematomal inflammation in intracerebral hemorrhage. We examined whether the combination treatment has additive effects in experimental intracerebral hemorrhage (ICH). ICH was induced using stereotaxic infusion of collagenase into brains of adult rats. After the induction of ICH, rats were treated with intraperitoneal injection of memantine (20 mg/kg), celecoxib (20 mg/kg) or both agents. Only vehicles were administrated in rats of the control group. Results showed that the combination treatment of memantine and celecoxib reduced both hematoma volume and brain edema. Combination treatment also induced the better functional recovery with further attenuation of cerebral inflammation and apoptosis compared to the control group. When compared to the single agent groups, the combination treatment showed better effects in neuroprotection and anti-inflammation. These results suggest the feasible combined application of memantine and celecoxib in ICH treatment. | en |
dc.description.sponsorship | This study was supported by a Korean Research Foundation
Grant funded by theKorean Government (MOEHRD, Basic Research Promotion Fund, KRF-2005-015-E00182). | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Intracerebral hemorrhage | en |
dc.subject | Memantine | en |
dc.subject | Celecoxib | en |
dc.subject | Anti-inflammation | en |
dc.subject | Excitotoxicity | en |
dc.title | Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신동인 | - |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 송은철 | - |
dc.contributor.AlternativeAuthor | 김정민 | - |
dc.contributor.AlternativeAuthor | 박동규 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.identifier.doi | 10.1016/j.neulet.2006.10.050 | - |
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