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Effects of dexamethasone on the expression of transforming growth factor-beta in the mouse model of allergic rhinitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Sin | - |
dc.contributor.author | Won, Tae-Bin | - |
dc.contributor.author | Kim, Jeong-Whun | - |
dc.contributor.author | Rhee, Chae-Seo | - |
dc.contributor.author | Lee, Chul-Hee | - |
dc.contributor.author | Hong, Seok-Chan | - |
dc.contributor.author | Min, Yang-Gi | - |
dc.date.accessioned | 2009-11-04T22:32:49Z | - |
dc.date.available | 2009-11-04T22:32:49Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Laryngoscope 2007;117:1323-1328 | en |
dc.identifier.issn | 0023-852X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17762268 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11174 | - |
dc.description.abstract | OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the effect of dexamethasone on the expression of transforming growth factor (TGF)-beta in the mouse model of allergic rhinitis. STUDY DESIGN: Female BALB/c mice were randomly assigned to four groups, including two control groups and two treatment groups. METHODS: General sensitization and local challenge were performed with ovalbumin (OVA). In the treatment groups, dexamethasone was injected intraperitoneally 3 hours before general sensitization or local challenge. Symptom score, eosinophil infiltration, and immunostaining for TGF-beta1 and CD4 in nasal mucosa, and TGF-beta1 and OVA-specific immunoglobulin E (IgE) in sera were analyzed. RESULTS: Dexamethasone administration before general sensitization reduced the symptom score, OVA-specific IgE, and eosinophil infiltration and increased the serum level of TGF-beta1 significantly. Dexamethasone administration before local challenge reduced only the eosinophil infiltration significantly. Immunoreactivity of TGF-beta1 and CD4 was lower in both treatment groups. CONCLUSION: These results suggest that dexamethasone may play an important role in the regulation of allergic reactions by at least two mechanisms; one by suppressing allergic sensitization through decrease of CD4+ T cells and increase of TGF-beta, and the other by suppressing late allergic reactions through the inhibition of proliferation and chemotaxis of inflammatory cells such as eosinophils. | en |
dc.language.iso | en | - |
dc.publisher | Laryngoscope | en |
dc.subject | Allergy | en |
dc.subject | dexamethasone | en |
dc.subject | TGF- | en |
dc.subject | CD4 T cell | en |
dc.subject | regulatory T cell | en |
dc.subject | Glucocorticoids/*therapeutic use | en |
dc.subject | Immunoglobulin E/metabolism | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Leukocyte Count | en |
dc.subject | Mice, Inbred BALB C | en |
dc.subject | Nasal Mucosa/immunology/metabolism/pathology | en |
dc.subject | Ovalbumin/toxicity | en |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | en |
dc.subject | Transforming Growth Factor beta/*genetics/metabolism | en |
dc.title | Effects of dexamethasone on the expression of transforming growth factor-beta in the mouse model of allergic rhinitis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이승신 | - |
dc.contributor.AlternativeAuthor | 원태빈 | - |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 이재서 | - |
dc.contributor.AlternativeAuthor | 이철희 | - |
dc.contributor.AlternativeAuthor | 홍석찬 | - |
dc.contributor.AlternativeAuthor | 민양기 | - |
dc.identifier.doi | 10.1097/MLG.0b013e318064e84d | - |
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