Publications
Detailed Information
KCNQ1/KCNE1 K+ channel and P2Y4 receptor are co-expressed from the time of birth in the apical membrane of rat strial marginal cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hur, Dong Gu | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.contributor.author | Oh, Seung-Ha | - |
dc.contributor.author | Kim, Young Ho | - |
dc.contributor.author | Lee, Jin Hee | - |
dc.contributor.author | Shin, Dong Hoon | - |
dc.contributor.author | Chang, Sun O. | - |
dc.contributor.author | Kim, Chong-Sun | - |
dc.date.accessioned | 2009-11-04T23:18:56Z | - |
dc.date.available | 2009-11-04T23:18:56Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Acta Otolaryngol Suppl 2007;558:30-5 | en |
dc.identifier.issn | 0365-5237 (Print) | - |
dc.identifier.uri | http://www.informaworld.com/smpp/content~db=all?content=10.1080/03655230701624830 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17882567 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11192 | - |
dc.description.abstract | CONCLUSION: KCNQ1/KCNE1 K(+) channels and P2Y(4) receptors are expressed in the apical membrane of rat strial marginal cells from postnatal day 1 (P1) and maintained throughout development. OBJECTIVES: The purpose of the present study was to investigate the developmental expression of KCNQ1/KCNE1 K(+) channel and of P2Y(4), which is an important metabotropic regulator of KCNQ1/KCNE1 K(+) channel in strial marginal cells. MATERIALS AND METHODS: Sprague-Dawley rats at different stages of development (P1, P3, P5, P7, P14, and P21) were studied. The spiral ligament with the stria vascularis was detached from the cartilaginous or bony cochlea and prepared for a voltage-sensitive vibrating probe and immunohistochemistry. RESULTS: Chromanol 293B, a blocker of KCNQ1/KCNE1 K(+) channel, inhibited short-circuit currents (I ( sc )) from P1 to P21. Similarly, I ( sc ) were found to be decreased by uridine 5'-triphosphate at all ages. The antagonist profiles indicated that the apical P2Y receptor is P2Y(4) subtype. KCNQ1, KCNE1, and P2Y(4) were immunolocalized in the apical region of stria vascularis at P1. | en |
dc.description.sponsorship | This work was supported by grant no 02-2006-027
from the SNUBH Research Fund. | en |
dc.language.iso | en | en |
dc.publisher | Informa Healthcare | en |
dc.subject | KCNQ1/KCNE1 K channel | en |
dc.subject | P2Y4 | en |
dc.subject | strial marginal cell | en |
dc.subject | cochlea, rat | en |
dc.subject | voltage-sensitive vibrating probe | en |
dc.title | KCNQ1/KCNE1 K+ channel and P2Y4 receptor are co-expressed from the time of birth in the apical membrane of rat strial marginal cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 허동구 | - |
dc.contributor.AlternativeAuthor | 이준호 | - |
dc.contributor.AlternativeAuthor | 오승하 | - |
dc.contributor.AlternativeAuthor | 김영호 | - |
dc.contributor.AlternativeAuthor | 이진희 | - |
dc.contributor.AlternativeAuthor | 신동훈 | - |
dc.contributor.AlternativeAuthor | 장선오 | - |
dc.contributor.AlternativeAuthor | 김종선 | - |
dc.identifier.doi | 10.1080/03655230701624830 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.