Publications

Detailed Information

Coagulation parameters and plasma total homocysteine levels in Behcet's disease

DC Field Value Language
dc.contributor.authorLee, Yun Jong-
dc.contributor.authorKang, Seong Wook-
dc.contributor.authorYang, Jong In-
dc.contributor.authorChoi, Young-Mi-
dc.contributor.authorSheen, Donghyuk-
dc.contributor.authorLee, Eun Bong-
dc.contributor.authorChoi, Sang-Woon-
dc.contributor.authorSong, Yeong Wook-
dc.date.accessioned2009-11-05T23:00:47Z-
dc.date.available2009-11-05T23:00:47Z-
dc.date.issued2002-
dc.identifier.citationThromb Res 2002;106(1):19-24en
dc.identifier.issn0049-3848 (Print)-
dc.identifier.issnhttp://dx.doi.org/10.1016/S0049-3848(02)00085-3-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12165284-
dc.identifier.urihttps://hdl.handle.net/10371/11307-
dc.description.abstractBehcet's disease (BD) is a multisystemic inflammatory disorder of unknown etiology that is sometimes associated with thrombosis in addition to systemic manifestations. However, the mechanism of hypercoagulability is not known. We evaluated the coagulation and fibrinolytic activities and the plasma total homocysteine levels of Korean BD patients in two cross-sectional studies. In the first study regarding coagulation and fibrinolytic activities, the levels of fibrinogen and von Willebrand factor (vWF) antigen were significantly higher in the BD patients than in the healthy controls (387.7+/-24.3 versus 240.6+/-8.8 mg/dl, p<0.001, and 131.9+/-8.8 versus 105.2+/-0.3%, p<0.01, respectively). The level of antithrombin III (AT III) was significantly lower in the BD patients (92.8+/-3.2 versus 106.3+/-2.6%, p<0.005). No differences were observed in the levels of plasminogen, protein C, or protein S activities. Activated protein C (APC) resistance was not observed in any BD patients. In the second study, the plasma total homocysteine levels of patients with a history of thrombosis (11.9+/-3.0 micromol/l) or disease activity (12.5+/-3.8 micromol/l) were found to be significantly higher than those of the controls (9.2+/-2.6 micromol/l, p<0.05, both). The plasma homocysteine concentrations in the thrombosis patients were positively correlated with plasma vWF levels; a relationship which suggests injury of the vascular endothelium (Spearman coefficient=0.857, p<0.01). Therefore, coagulation abnormality did not contribute to thrombotic complications, and higher levels of homocysteine may play a role in the hypercoagulablity of BD patients.en
dc.description.sponsorshipThis project has been supported by Grant No. 03-1997-
0101 from the Seoul National University Hospital Research
Fund and in part by the Cancer Research Foundation of
America (SWC) and by the U.S. Department of Agriculture,
under Agreement No. 581950-9-001 (SWC).
en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectBehcet’s diseaseen
dc.subjectThrombosisen
dc.subjectHomocysteineen
dc.subjectvon Willebrand factoren
dc.titleCoagulation parameters and plasma total homocysteine levels in Behcet's diseaseen
dc.typeArticleen
dc.contributor.AlternativeAuthor이윤종-
dc.contributor.AlternativeAuthor강성욱-
dc.contributor.AlternativeAuthor양종인-
dc.contributor.AlternativeAuthor최영미-
dc.contributor.AlternativeAuthor신동혁-
dc.contributor.AlternativeAuthor이은봉-
dc.contributor.AlternativeAuthor최상운-
dc.contributor.AlternativeAuthor송영욱-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share