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Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Young-Myeong | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.contributor.author | Kwon, Ho Jeong | - |
dc.date.accessioned | 2009-11-09T04:15:15Z | - |
dc.date.available | 2009-11-09T04:15:15Z | - |
dc.date.issued | 2007-09-07 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2007 Nov 3;362(4):848-52. Epub 2007 Aug 28. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4PHSK6Y-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ae1d619d63f7d9cf3bc72859edadc462 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17803958 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11568 | - |
dc.description.abstract | Neovascularization in the eye is the most common cause of blindness in all age groups; retinopathy of prematurity (ROP), diabetic retinopathy, and age-related macular degeneration. Despite current advances in surgical treatments, ROP remains as the most serious problem of vision loss in children. Here, we report that homoisoflavanone, a natural product from Cremastra appendiculata, significantly reduces retinal neovascularization in a mouse model of ROP. Homoisoflavanone inhibited the cell growth of HUVECs, but its cytotoxic effect was not observed in a concentration range of 1-20 microM. HUVECs population gradually increased in G2/M phase and reduced in G0/G1 and S phases after exposure to the compound. Homoisoflavanone decreased the level of cdc2 expression whereas the level of p21WAF1 expression was increased in a dose-dependent manner. These data demonstrate that homoisoflavanone could inhibit retinal neovascularization and be applied in the treatment of other vasoproliferative retinopathies. | en |
dc.language.iso | en | - |
dc.publisher | Academic Press | en |
dc.subject | Animals | en |
dc.subject | CDC2 Protein Kinase/*metabolism | en |
dc.subject | Cell Cycle/drug effects | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Down-Regulation/drug effects | en |
dc.subject | Humans | en |
dc.subject | Infant, Newborn | en |
dc.subject | Isoflavones/*therapeutic use | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Retinal Neovascularization/*drug therapy/*metabolism/pathology | en |
dc.subject | Retinopathy of Prematurity/*drug therapy/*metabolism/pathology | en |
dc.title | Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 김기현 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김영명 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.contributor.AlternativeAuthor | 권호정 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.08.100 | - |
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