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Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance: nationwide survival data in Korea--a report from the Korean Breast Cancer Society
DC Field | Value | Language |
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dc.contributor.author | Ahn, Sei Hyun | - |
dc.contributor.author | Son, Byung Ho | - |
dc.contributor.author | Kim, Seok Won | - |
dc.contributor.author | Kim, Seung Il | - |
dc.contributor.author | Jeong, Joon | - |
dc.contributor.author | Ko, Seung-Sang | - |
dc.contributor.author | Han, Wonshik | - |
dc.date.accessioned | 2009-11-09T07:00:10Z | - |
dc.date.available | 2009-11-09T07:00:10Z | - |
dc.date.issued | 2007-05-23 | - |
dc.identifier.citation | J Clin Oncol. 2007 Jun 10;25(17):2360-8. Epub 2007 May 21. | en |
dc.identifier.issn | 1527-7755 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17515570 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11610 | - |
dc.description.abstract | PURPOSE: Breast cancer in very young women (age < 35 years) is uncommon and poorly understood. We sought to evaluate the prognosis and treatment response of these patients compared with women ages 35 to 50 years. PATIENTS AND METHODS: We analyzed data from 9,885 breast cancer patients age < or = 50 years who were part of the Korean Breast Cancer Society registration program between 1992 and 2001. The overall survival (OS) and breast cancer-specific survival (BCSS) were compared between age groups. RESULTS: One thousand four hundred forty-four patients (14.6%) were younger than age 35 and 8,441 (85.4%) patients were between 35 and 50 years of age. Younger patients had significantly higher T-stage and higher lymph node positivity and lower hormone receptor expression than older patients. Younger patients had a greater probability of death than older patients, regardless of tumor size or lymph node status. The survival difference was significant for patients with positive or unknown hormone receptor status (P < .0001), but not for patients with negative hormone receptor status. In a multivariate analysis, the interaction term of young age and hormone receptor positivity was significant for OS and BCSS with a hazard ratio for OS of 2.13 (95% CI, 1.52 to 2.98). The significant survival benefit from adjuvant hormone therapy after chemotherapy observed in older patients (hazard ratio for OS, 0.61; 95% CI, 0.47 to 0.79; P = .001) could not be seen in younger patients (P > .05). CONCLUSION: Younger patients (age < 35) showed worse prognosis than older patients (age, 35 to 50 years) only in the hormone receptor-unknown or hormone receptor-positive subgroups. Adjuvant tamoxifen therapy might provide less survival benefit when added to chemotherapy in very young breast cancer patients. | en |
dc.language.iso | en | - |
dc.publisher | American Society of Clinical Oncology | en |
dc.subject | Adult | en |
dc.subject | Age Factors | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use | en |
dc.subject | Breast Neoplasms/drug therapy/metabolism/*mortality | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Middle Aged | en |
dc.subject | Prognosis | en |
dc.subject | Receptors, Estrogen/*metabolism | en |
dc.subject | Receptors, Progesterone/*metabolism | en |
dc.subject | Registries | en |
dc.subject | Selective Estrogen Receptor Modulators/therapeutic use | en |
dc.subject | Tamoxifen/*therapeutic use | en |
dc.subject | Drug Resistance, Neoplasm | - |
dc.title | Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance: nationwide survival data in Korea--a report from the Korean Breast Cancer Society | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.contributor.AlternativeAuthor | 손병호 | - |
dc.contributor.AlternativeAuthor | 김석원 | - |
dc.contributor.AlternativeAuthor | 김승일 | - |
dc.contributor.AlternativeAuthor | 정준 | - |
dc.contributor.AlternativeAuthor | 고승상 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.identifier.doi | 10.3754 | - |
dc.identifier.doi | 10.1200/JCO.2006.10.3754 | - |
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