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Imaging Single-mRNA Localization and Translation in Live Neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Byung Hun | - |
dc.contributor.author | Bae, Seong-Woo | - |
dc.contributor.author | Shim, Jaeyoun Jay | - |
dc.contributor.author | Park, Sung Young | - |
dc.contributor.author | Park, Hye Yoon | - |
dc.date.accessioned | 2017-04-19T00:19:48Z | - |
dc.date.available | 2017-11-10T11:08:08Z | - |
dc.date.created | 2018-08-07 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | MOLECULES AND CELLS, Vol.39 No.12, pp.841-846 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116885 | - |
dc.description.abstract | Local protein synthesis mediates precise spatio-temporal regulation of gene expression for neuronal functions such as long-term plasticity, axon guidance and regeneration. To reveal the underlying mechanisms of local translation, it is crucial to understand mRNA transport, localization and translation in live neurons. Among various techniques for mRNA analysis, fluorescence microscopy has been widely used as the most direct method to study localization of mRNA. Live-cell imaging of single RNA molecules is particularly advantageous to dissect the highly heterogeneous and dynamic nature of messenger ribonucleoprotein (mRNP) complexes in neurons. Here, we review recent advances in the study of mRNA localization and translation in live neurons using novel techniques for single-RNA imaging. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Imaging Single-mRNA Localization and Translation in Live Neurons | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이병훈 | - |
dc.contributor.AlternativeAuthor | 배성우 | - |
dc.contributor.AlternativeAuthor | 심재윤 | - |
dc.contributor.AlternativeAuthor | 박혜윤 | - |
dc.author.alternative | 박성영 | - |
dc.identifier.doi | 10.14348/molcells.2016.0277 | - |
dc.citation.journaltitle | MOLECULES AND CELLS | - |
dc.identifier.wosid | 000393179300001 | - |
dc.identifier.scopusid | 2-s2.0-85018439270 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201619561 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079734 | - |
dc.description.srnd | CITE_RATE:2.67 | - |
dc.description.srnd | DEPT_NM:물리·천문학부 | - |
dc.description.srnd | EMAIL:hyeyoon.park@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 846 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 841 | - |
dc.citation.volume | 39 | - |
dc.identifier.kciid | ART002190143 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Hye Yoon | - |
dc.identifier.srnd | T201619561 | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LOCAL PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | GROWTH CONES | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | FINE-STRUCTURE | - |
dc.subject.keywordPlus | MYOSIN-VA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordAuthor | live-cell imaging | - |
dc.subject.keywordAuthor | local translation | - |
dc.subject.keywordAuthor | MS2-GFP | - |
dc.subject.keywordAuthor | RNA localization | - |
dc.subject.keywordAuthor | single-molecule imaging | - |
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