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Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols
26848214

Cited 16 time in Web of Science Cited 16 time in Scopus
Authors
Shin, Hyoseung; Cho, A-Ri; Kim, Dong Young; Munkhbayer, Semchin; Choi, Soon-Jin; Jang, Sunhyae; Kim, Seong Ho; Shin, Hyeon-Cheol; Kwon, Ohsang
Issue Date
2015-05-04
Publisher
The Korean Dermatological Association and The Korean Society for Investigative Dermatology
Citation
ANNALS OF DERMATOLOGY Vol.28 No.1, pp. 15-21
Keywords
Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols의약학Ecklonia cavaHairInsulin-like growth factor-IOxidative stressPolyphenolsVascular endothelial growth factor A
Abstract
Background: Ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. E. cava polyphenols (ECPs) are known to increase fibroblast survival. The human dermal papilla cell (hDPC) has the properties of mesenchymal-origin fibroblasts. Objective: This study aims to investigate the effect of ECPs on human hair growth promotion in vitro and ex vivo. Methods: MTT assays were conducted to examine the effect of ECPs on hDPC proliferation. Hair growth was measured using ex-vivo hair follicle cultures. Real-time polymerase chain reaction was performed to evaluate the mRNA expression of various growth factors in ECP-treated hDPCs. Results: Treatment with 10 μg/ml purified polyphenols from E. cava (PPE) enhanced the proliferation of hDPCs 30.3% more than in the negative control (p<0.001). Furthermore, 0.1 μg/ml PPE extended the human hair shaft 30.8% longer than the negative control over 9 days (p<0.05). Insulin-like growth factor-1 (IGF-1) mRNA expression increased 3.2-fold in hDPCs following treatment with 6 μg/ml PPE (p<0.05). Vascular endothelial growth factor (VEGF) mRNA expression was also increased 2.0-fold by 3 μg/ml PPE (p<0.05). Treatment with 10 μg/ml PPE reduced oxidative stress in hDPCs (p<0.05). Conclusion: These results suggest that PPE could enhance human hair growth. This can be explained by hDPC proliferation coupled with increases in growth factors such as IGF-1 and VEGF. Reducing oxidative stress is also thought to help increase hDPCs. These favorable results suggest that PPE is a promising therapeutic candidate for hair loss.
ISSN
1013-9087
Language
English
URI
http://hdl.handle.net/10371/116922
DOI
https://doi.org/10.5021/ad.2016.28.1.15
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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