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Detection of aquaporin-4 antibody using aquaporin-4 extracellular loop-based carbon nanotube biosensor for the diagnosis of neuromyelitis optica
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Manki | - |
dc.contributor.author | Kim, Daesan | - |
dc.contributor.author | Park, Kyung Seok | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Hong, Seunghun | - |
dc.date.accessioned | 2017-04-21T02:30:00Z | - |
dc.date.available | 2017-05-10T16:59:57Z | - |
dc.date.issued | 2015-11-12 | - |
dc.identifier.citation | Biosensors and Bioelectronics Vol.78, pp. 87-91 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116990 | - |
dc.description.abstract | Here we propose a carbon nanotube (CNT) field-effect transistor (FET) functionalized with aquaporin-4 (AQP4) extracellular loop peptides for the rapid detection of AQP4 antibody without pretreatment. Neuromyelitis optica (NMO) is a rare disease of the central nerve system that affects the optic nerves and the spinal cord. NMO-IgG, a serum antibody in patients, is highly specific for NMO and targets AQP4. We synthesized AQP4 extracellular loop peptides, known as primary autoimmune target in NMO, and immobilized them onto CNT-FET. The sensor showed p-type FET characteristics after the functionalization of peptides. The sensor was able to detect antibody with a detection limit of 1 ng l-1 . Moreover, AQP4 antibody in human serum was detected without any pretreatment. These results indicate that the biosensor can be used for rapid and simple detection of NMO antibody. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier B.V. | en |
dc.subject | Neuromyelitis optica | en |
dc.subject | Aquaporin-4 | en |
dc.subject | Carbon nanotube | - |
dc.subject | Field-effect transistor | - |
dc.title | Detection of aquaporin-4 antibody using aquaporin-4 extracellular loop-based carbon nanotube biosensor for the diagnosis of neuromyelitis optica | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 손만기 | - |
dc.contributor.AlternativeAuthor | 김대산 | - |
dc.contributor.AlternativeAuthor | 박경석 | - |
dc.contributor.AlternativeAuthor | 홍승훈 | - |
dc.contributor.AlternativeAuthor | 박태현 | - |
dc.identifier.doi | 10.1016/j.bios.2015.11.029 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201623708 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A002014 | - |
dc.description.srnd | CITE_RATE:7.476 | - |
dc.description.srnd | FILENAME:1. (2016.04) Detection of aquaporin-4 antibody using aquaporin-4 extracellular.pdf | - |
dc.description.srnd | DEPT_NM:화학생물공학부 | - |
dc.description.srnd | EMAIL:thpark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/daebf249-842a-4b5c-bbc2-0b51d01edbb2/link | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | T201623708 | - |
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