Publications
Detailed Information
Cattle genome-wide analysis reveals genetic signatures in trypanotolerant NDama
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soo-Jin | - |
dc.contributor.author | Ka, Sojeong | - |
dc.contributor.author | Ha, Jung-Woo | - |
dc.contributor.author | Kim, Jaemin | - |
dc.contributor.author | Yoo, DongAhn | - |
dc.contributor.author | Kim, Kwondo | - |
dc.contributor.author | Lee, Hak-Kyo | - |
dc.contributor.author | Lim, Dajeong | - |
dc.contributor.author | Cho, Seoae | - |
dc.contributor.author | Hanotte, Olivier | - |
dc.contributor.author | Mwai, Okeyo Ally | - |
dc.contributor.author | Dessie, Tadelle | - |
dc.contributor.author | Kemp, Stephen | - |
dc.contributor.author | Oh, Sung Jong | - |
dc.contributor.author | Kim, Heebal | - |
dc.date.accessioned | 2017-05-15T00:15:08Z | - |
dc.date.available | 2017-05-15T09:20:52Z | - |
dc.date.issued | 2017-05-12 | - |
dc.identifier.citation | BMC Genomics, 18(1):371 | ko_KR |
dc.identifier.uri | 10.1186/s12864-017-3742-2 | - |
dc.identifier.uri | https://hdl.handle.net/10371/117603 | - |
dc.description.abstract | Background
Indigenous cattle in Africa have adapted to various local environments to acquire superior phenotypes that enhance their survival under harsh conditions. While many studies investigated the adaptation of overall African cattle, genetic characteristics of each breed have been poorly studied. Results We performed the comparative genome-wide analysis to assess evidence for subspeciation within species at the genetic level in trypanotolerant NDama cattle. We analysed genetic variation patterns in NDama from the genomes of 101 cattle breeds including 48 samples of five indigenous African cattle breeds and 53 samples of various commercial breeds. Analysis of SNP variances between cattle breeds using wMI, XP-CLR, and XP-EHH detected genes containing NDama-specific genetic variants and their potential associations. Functional annotation analysis revealed that these genes are associated with ossification, neurological and immune system. Particularly, the genes involved in bone formation indicate that local adaptation of NDama may engage in skeletal growth as well as immune systems. Conclusions Our results imply that NDama might have acquired distinct genotypes associated with growth and regulation of regional diseases including trypanosomiasis. Moreover, this study offers significant insights into identifying genetic signatures for natural and artificial selection of diverse African cattle breeds. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Cattle genome | ko_KR |
dc.subject | Trypanotolerant N’Dama | ko_KR |
dc.subject | SNPs | ko_KR |
dc.subject | Genetic signature | ko_KR |
dc.subject | Comparative genome-wide analysis | ko_KR |
dc.title | Cattle genome-wide analysis reveals genetic signatures in trypanotolerant NDama | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김수진 | - |
dc.contributor.AlternativeAuthor | 가소정 | - |
dc.contributor.AlternativeAuthor | 하정우 | - |
dc.contributor.AlternativeAuthor | 김재민 | - |
dc.contributor.AlternativeAuthor | 유동안 | - |
dc.contributor.AlternativeAuthor | 김권도 | - |
dc.contributor.AlternativeAuthor | 이학교 | - |
dc.contributor.AlternativeAuthor | 임다정 | - |
dc.contributor.AlternativeAuthor | 조서애 | - |
dc.contributor.AlternativeAuthor | 오성종 | - |
dc.contributor.AlternativeAuthor | 김희발 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-05-14T03:28:13Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.