S-Space College of Medicine/School of Medicine (의과대학/대학원) Ophthalmology (안과학전공) Journal Papers (저널논문_안과학전공)
Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results
- Kim, Tae-Woo; Park, Un-Chul; Park, Ki Ho; Kim, Dong Myung
- Issue Date
- Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1635-41.
- Adult; Aged; Aged, 80 and over; Female; Glaucoma/*diagnosis; Humans; Intraocular Pressure; Male; Middle Aged; Nerve Fibers/*pathology; Optic Nerve Diseases/*diagnosis; *Perimetry; Photography; Retinal Ganglion Cells/*pathology; Retrospective Studies; Scotoma/diagnosis; Sensitivity and Specificity; Tomography, Optical Coherence/*methods; Visual Fields
- PURPOSE: To evaluate the ability of Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) with its internal normative database to discriminate between healthy eyes and eyes with a localized retinal nerve fiber layer (RNFL) defect not accompanied by a perimetric defect according to standard automated perimetry (SAP) (i.e., a preperimetric localized RNFL defect). METHODS: Data were retrospectively reviewed from 49 eyes of 49 subjects with preperimetric localized RNFL defects, and 49 healthy control eyes of 49 age-matched subjects, with classification into each group based primarily on red-free fundus photography RESULTS: The sensitivity and specificity of various OCT RNFL thickness parameters for identifying subjects with preperimetric localized RNFL defects was determined. In addition, the topographic relationship between the OCT-measured RNFL thickness and the localized RNFL defect location according to red-free fundus photography (i.e., the red-free RNFL defect) was examined. results. The sensitivity of the Stratus OCT RNFL thickness parameters ranged from 2.0% to 40.8%. The highest sensitivity was yielded using a criterion of > or =1 clock hour that were abnormal at the 5% level, which had a specificity of 85.7%. The OCT-measured RNFL thickness showed excellent topographic agreement with the red-free RNFL defect location. CONCLUSIONS: Although the sensitivity of current Stratus OCT RNFL thickness parameters is low for preperimetric localized RNFL defects, it appears that OCT has the potential to recognize such defects. Further study is needed to develop new analytical methods that will increase OCT sensitivity for identifying preperimetric localized RNFL damage.
- 0146-0404 (Print)