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Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results

Cited 63 time in Web of Science Cited 69 time in Scopus
Authors
Kim, Tae-Woo; Park, Un-Chul; Park, Ki Ho; Kim, Dong Myung
Issue Date
2007-03-29
Publisher
Association for Research in Vision and Ophthalmology
Citation
Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1635-41.
Keywords
AdultAgedAged, 80 and overFemaleGlaucoma/*diagnosisHumansIntraocular PressureMaleMiddle AgedNerve Fibers/*pathologyOptic Nerve Diseases/*diagnosis*PerimetryPhotographyRetinal Ganglion Cells/*pathologyRetrospective StudiesScotoma/diagnosisSensitivity and SpecificityTomography, Optical Coherence/*methodsVisual Fields
Abstract
PURPOSE: To evaluate the ability of Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) with its internal normative database to discriminate between healthy eyes and eyes with a localized retinal nerve fiber layer (RNFL) defect not accompanied by a perimetric defect according to standard automated perimetry (SAP) (i.e., a preperimetric localized RNFL defect). METHODS: Data were retrospectively reviewed from 49 eyes of 49 subjects with preperimetric localized RNFL defects, and 49 healthy control eyes of 49 age-matched subjects, with classification into each group based primarily on red-free fundus photography RESULTS: The sensitivity and specificity of various OCT RNFL thickness parameters for identifying subjects with preperimetric localized RNFL defects was determined. In addition, the topographic relationship between the OCT-measured RNFL thickness and the localized RNFL defect location according to red-free fundus photography (i.e., the red-free RNFL defect) was examined. results. The sensitivity of the Stratus OCT RNFL thickness parameters ranged from 2.0% to 40.8%. The highest sensitivity was yielded using a criterion of > or =1 clock hour that were abnormal at the 5% level, which had a specificity of 85.7%. The OCT-measured RNFL thickness showed excellent topographic agreement with the red-free RNFL defect location. CONCLUSIONS: Although the sensitivity of current Stratus OCT RNFL thickness parameters is low for preperimetric localized RNFL defects, it appears that OCT has the potential to recognize such defects. Further study is needed to develop new analytical methods that will increase OCT sensitivity for identifying preperimetric localized RNFL damage.
ISSN
0146-0404 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17389494

http://hdl.handle.net/10371/11782
DOI
https://doi.org/10.1167/iovs.06-0800
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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