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Clinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablation
DC Field | Value | Language |
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dc.contributor.author | Chung, J-K | - |
dc.contributor.author | Park, Y J | - |
dc.contributor.author | Kim, T Y | - |
dc.contributor.author | So, Y | - |
dc.contributor.author | Kim, S-K | - |
dc.contributor.author | Park, D J | - |
dc.contributor.author | Lee, D S | - |
dc.contributor.author | Lee, M C | - |
dc.contributor.author | Cho, B Y | - |
dc.date.accessioned | 2009-11-10 | - |
dc.date.available | 2009-11-10 | - |
dc.date.issued | 2002-08-03 | - |
dc.identifier.citation | Clin Endocrinol (Oxf). 2002 Aug;57(2):215-21. | en |
dc.identifier.issn | 0300-0664 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12153600 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11796 | - |
dc.description.abstract | OBJECTIVE: This study was designed to investigate whether an elevated serum antithyroglobulin antibody (TgAb) reflects cancer recurrence in thyroglobulin (Tg)-undetectable patients with differentiated thyroid carcinoma (DTC) after thyroid ablation. DESIGN: We measured serum TgAb level and evaluated the disease status in 226 DTC patients who had undergone remnant ablation and showed an undetectable Tg result as assessed by immunoradiometric assay. MEASUREMENTS: Radioligand assay of TgAb was performed. Recurrence was assessed by 131I scan, 18F-fluorodeoxyglucose positron emission tomography, sonography, computed tomography, or by surgical operation. RESULTS: Fifty-one patients (22.6%) of the Tg-undetectable patients showed positive TgAb, and 25 (49.0%) of these were confirmed with recurrence. The recurrence rate of TgAb-positive patients was higher than that of TgAb-negative patients (3.4%; P < 0.0001). During follow-up, 73.1% of the disease-free patients showed spontaneously decreased TgAb levels. A total of 71.4% of patients with recurrent cancer, who showed responses to surgical operation or radio-iodine treatment, also showed a decreased TgAb level. CONCLUSIONS: Persistently elevated TgAb levels appear to serve as a useful marker for recurrent or persistent DTC in patients with undetectable serum Tg results. Thus, the routine measurement of TgAb in such patient populations may be indicated. | en |
dc.language.iso | en | en |
dc.publisher | Blackwell Publishing | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Autoantibodies/*blood | en |
dc.subject | Combined Modality Therapy | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Immunoradiometric Assay | en |
dc.subject | Iodine Radioisotopes/therapeutic use | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Recurrence, Local/*diagnosis | en |
dc.subject | Prognosis | en |
dc.subject | Thyroglobulin/*immunology | en |
dc.subject | Thyroid Neoplasms/*blood/radiotherapy/surgery | en |
dc.subject | Thyroidectomy | en |
dc.subject | Tumor Markers, Biological/*blood | en |
dc.title | Clinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablation | en |
dc.type | Article | en |
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