Browse

Clinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablation

DC Field Value Language
dc.contributor.authorChung, J-K-
dc.contributor.authorPark, Y J-
dc.contributor.authorKim, T Y-
dc.contributor.authorSo, Y-
dc.contributor.authorKim, S-K-
dc.contributor.authorPark, D J-
dc.contributor.authorLee, D S-
dc.contributor.authorLee, M C-
dc.contributor.authorCho, B Y-
dc.date.accessioned2009-11-10-
dc.date.available2009-11-10-
dc.date.issued2002-08-03-
dc.identifier.citationClin Endocrinol (Oxf). 2002 Aug;57(2):215-21.en
dc.identifier.issn0300-0664 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12153600-
dc.identifier.urihttps://hdl.handle.net/10371/11796-
dc.description.abstractOBJECTIVE: This study was designed to investigate whether an elevated serum antithyroglobulin antibody (TgAb) reflects cancer recurrence in thyroglobulin (Tg)-undetectable patients with differentiated thyroid carcinoma (DTC) after thyroid ablation. DESIGN: We measured serum TgAb level and evaluated the disease status in 226 DTC patients who had undergone remnant ablation and showed an undetectable Tg result as assessed by immunoradiometric assay. MEASUREMENTS: Radioligand assay of TgAb was performed. Recurrence was assessed by 131I scan, 18F-fluorodeoxyglucose positron emission tomography, sonography, computed tomography, or by surgical operation. RESULTS: Fifty-one patients (22.6%) of the Tg-undetectable patients showed positive TgAb, and 25 (49.0%) of these were confirmed with recurrence. The recurrence rate of TgAb-positive patients was higher than that of TgAb-negative patients (3.4%; P < 0.0001). During follow-up, 73.1% of the disease-free patients showed spontaneously decreased TgAb levels. A total of 71.4% of patients with recurrent cancer, who showed responses to surgical operation or radio-iodine treatment, also showed a decreased TgAb level. CONCLUSIONS: Persistently elevated TgAb levels appear to serve as a useful marker for recurrent or persistent DTC in patients with undetectable serum Tg results. Thus, the routine measurement of TgAb in such patient populations may be indicated.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAutoantibodies/*blooden
dc.subjectCombined Modality Therapyen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectImmunoradiometric Assayen
dc.subjectIodine Radioisotopes/therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Recurrence, Local/*diagnosisen
dc.subjectPrognosisen
dc.subjectThyroglobulin/*immunologyen
dc.subjectThyroid Neoplasms/*blood/radiotherapy/surgeryen
dc.subjectThyroidectomyen
dc.subjectTumor Markers, Biological/*blooden
dc.titleClinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablationen
dc.typeArticleen
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse