Asymmetric total synthesis of (+)-Bermudenynol through Intramolecular Amide Enolate Alkylation : 해양천연물 (+)-Bermudenynol의Intramolecular Amide Enolate Alkylation을 이용한 부제 전합성
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- 약학대학 약학과
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- 서울대학교 대학원
- Total Synthesis of Natural Products ; (+)-bermudenynol ; Intramolecular Amide Enolate Alkylation ; Vinyl Chloride-Containing Oxocene
- 학위논문 (박사)-- 서울대학교 대학원 : 약학과, 2014. 2. 이지우.
- A substrate-controlled asymmetric total synthesis of (+)-bermudenynol, a compact and synthetically challenging C15 Laurencia metabolite that contains several halogen atoms, is reported. The oxocene core, which contains a vinyl chloride, was constructed by an efficient and highly stereoselective intramolecular amide enolate alkylation (IAEA). This result showcases the broad utility of the IAEA methodology as a useful alternative for cases in which the ring-closing metathesis is inefficient.
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- College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Ph.D. / Sc.D._약학과)
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