Publications
Detailed Information
Asymmetric total synthesis of (+)-Bermudenynol through Intramolecular Amide Enolate Alkylation : 해양천연물 (+)-Bermudenynol의Intramolecular Amide Enolate Alkylation을 이용한 부제 전합성
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이지우 | - |
dc.contributor.author | 김규동 | - |
dc.date.accessioned | 2017-07-13T16:33:24Z | - |
dc.date.available | 2017-07-13T16:33:24Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.other | 000000017557 | - |
dc.identifier.uri | https://hdl.handle.net/10371/120063 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 약학과, 2014. 2. 이지우. | - |
dc.description.abstract | A substrate-controlled asymmetric total synthesis of (+)-bermudenynol, a compact and synthetically challenging C15 Laurencia metabolite that contains several halogen atoms, is reported. The oxocene core, which contains a vinyl chloride, was constructed by an efficient and highly stereoselective intramolecular amide enolate alkylation (IAEA). This result showcases the broad utility of the IAEA methodology as a useful alternative for cases in which the ring-closing metathesis is inefficient. | - |
dc.description.tableofcontents | Abstract i
1. Introduction 1 2. Results and Discussion 4 2.1 Retrosynthetic plan for (+)-Bermudenynol 4 2.2 Synthesis of Key Bromo Oxocene 2 5 2.3 Completion of the Synthesis 11 3. Conclusion 16 4. Experimental Section Part A : Experimental Procedures and Product Characterization 17 Part B : Spectroscopy Analysis 50 5. References 64 국문초록 69 | - |
dc.format | application/pdf | - |
dc.format.extent | 3236240 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Total Synthesis of Natural Products | - |
dc.subject | (+)-bermudenynol | - |
dc.subject | Intramolecular Amide Enolate Alkylation | - |
dc.subject | Vinyl Chloride-Containing Oxocene | - |
dc.subject.ddc | 615 | - |
dc.title | Asymmetric total synthesis of (+)-Bermudenynol through Intramolecular Amide Enolate Alkylation | - |
dc.title.alternative | 해양천연물 (+)-Bermudenynol의Intramolecular Amide Enolate Alkylation을 이용한 부제 전합성 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Gyudong Kim | - |
dc.description.degree | Doctor | - |
dc.citation.pages | i, 69 | - |
dc.contributor.affiliation | 약학대학 약학과 | - |
dc.date.awarded | 2014-02 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.