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Effect of resistance exercise on myokines and muscle functions in type 2 diabetes and aging

DC Field Value Language
dc.contributor.advisor송욱-
dc.contributor.author김희재-
dc.date.accessioned2017-07-13T17:07:46Z-
dc.date.available2017-07-13T17:07:46Z-
dc.date.issued2016-02-
dc.identifier.other000000133113-
dc.identifier.urihttps://hdl.handle.net/10371/120564-
dc.description학위논문 (박사)-- 서울대학교 대학원 : 체육교육과, 2016. 2. 송욱.-
dc.description.abstractSkeletal muscle has recently been recognized as an endocrine organ that produces and releases various cytokines termed myokines that are involved in the regulation of several physiological and metabolic pathways. Myokines are identified as cytokines and other peptides that are produced, expressed and released by muscle fibers and exert autocrine, paracrine or endocrine effects. These findings that the muscle derived myokines provide a conceptual basis and a whole new paradigm for understanding how muscle communicates with other organs, such as adipose tissue, liver, pancreas, bone, and brain. However, there was not enough evidence regard to evaluate the effect of resistance exercise on myokines in diabetes and aging model. In this dissertation, three-part of experiments were performed as follows-
dc.description.abstract1) Resistance training in type 2 diabetes rats, 2) Resistance training in aging mice, and 3) Resistance training in aging adults. The purpose was to investigate the effect of resistance exercise on myokines (including irisin and interleukin-15) and muscle functions in diabetes and aging models. In part 1 study, muscle quality and glucose tolerance were significantly improved in training group compared to control group. And IL-15 and irisin levels were significantly higher in soleus muscle of exercise group compared to control group. In addition, there were positive correlations between grip strength and level of
myokines in soleus muscle. In part 2 study, muscle mass and muscle strength were increased following resistance training. IL-15 and irisin were significantly increased in soleus muscle and circulating level. In addition, level of myokines and muscle strength has positive association in aging mice model. In part 3 study, muscle strength and muscle functions were significantly improved in trained elderly compared to sedentary elderly. Circulating myokines were significantly increased after 12 weeks of resistance training in trained group compared to their control group. In addition, changes of myokines were positively correlated with improvement of muscle strength in aging participants. Taken together with these results of dissertation, resistance training for aging and diabetic population was the efficient intervention to enhance the myokines and improve the muscle quality.
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dc.description.tableofcontentsI. Study Background 1
1.1 Identification of myokine 1
1.2 Role of myokines in aging 3
1.3 Role of myokines in diabetes. 6
1.4 Effect of resistance exercise on myokine 8

II. Experimental Researches (PART I, II, III) 10

PART I. Effect of resistance exercise on myokines in serum and skeletal muscles with improvement of glucose tolerance in type 2 diabetic rats 11
1. Introduction 12
2. Purpose of study 15
3. Methods and materials 16
4. Results 23
5. Discussion 34

PART II. Effect of resistance exercise on myokines and muscle functions in aging mice 44
1. Introduction 45
2. Purpose of study 47
3. Methods and materials 48
4. Results 55
5. Discussion 66

PART III. Effect of resistance exercise on myokines and muscle functions in elderly adults 70
1. Introduction 71
2. Purpose of study 73
3. Methods and meterials 74
4. Results 83
5. Discussion 98

III. Overall discussion 103

IV. Conclusion 107

References 109

Abstract (Korean) 133
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dc.formatapplication/pdf-
dc.format.extent2108137 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoko-
dc.publisher서울대학교 대학원-
dc.subjectresistance exercise-
dc.subjectmyokine-
dc.subjectirisin-
dc.subjectIL-15-
dc.subject.ddc796-
dc.titleEffect of resistance exercise on myokines and muscle functions in type 2 diabetes and aging-
dc.typeThesis-
dc.description.degreeDoctor-
dc.citation.pages134-
dc.contributor.affiliation사범대학 체육교육과-
dc.date.awarded2016-02-
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