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Detection of JC virus type 1 in peripheral lymphocytes, brain and cerebrospinal fluid from two Korean AIDS patients with progressive multifocal leukoencephalopathy

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dc.contributor.authorJeong, Byung-Hoon-
dc.contributor.authorJin, Jae-Kwang-
dc.contributor.authorChoi, Eun-Kyoung-
dc.contributor.authorKim, Kyung-Hoon-
dc.contributor.authorChoi, Kang-Won-
dc.contributor.authorOh, Myoung-Don-
dc.contributor.authorShin, Ki-Chul-
dc.contributor.authorKim, Yong-Sun-
dc.date.accessioned2009-11-13T04:34:03Z-
dc.date.available2009-11-13T04:34:03Z-
dc.date.issued2002-
dc.identifier.citationIntervirology 2002;45:94-100en
dc.identifier.issn0300-5526 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12145541-
dc.identifier.urihttps://hdl.handle.net/10371/12124-
dc.description.abstractThe human polyomavirus JC virus (JCV) is the etiologic agent of the fatal demyelinating central nervous system disease progressive multifocal leukoencephalopathy (PML), which occurs in 4-7% of AIDS patients. Two Korean AIDS patients with PML were assayed for JCV, and the virus was genotyped by polymerase chain reaction, DNA sequencing and phylogenetic analysis. Using immunohistochemical analysis, we also examined the distribution of JCV antigen in the brains of the patients. The JCV genome was detected in peripheral lymphocytes, brain and cerebrospinal fluid from these Korean PML patients. Although type 2 is the most common genotype in Asia, the genotype of the JCV in these two AIDS patients was characterized as type 1, which is of European origin. We found that JCV antigen was selectively detected in oligodendrocytes and astrocytes of the brains from these patients. Compared to the prototype type 1 (Mad-1), two different nucleotides (G-->C) in the KOR-1 strain identified here were found at positions 2488 and 2490 of the major capsid protein VP1 gene. In summary, this is the first report of PML in Korean AIDS patients; it is also the first isolation of JCV type 1 in PML in East Asians.en
dc.language.isoen-
dc.publisherKargeren
dc.subjectAIDS-Related Opportunistic Infections/*virologyen
dc.subjectBase Sequenceen
dc.subjectBrain/*virologyen
dc.subjectDNA, Viral/analysis/cerebrospinal fluiden
dc.subjectGenome, Viralen
dc.subjectGenotypeen
dc.subjectJC Virus/classification/genetics/*isolation & purificationen
dc.subjectLeukoencephalopathy, Progressive Multifocal/etiology/pathology/*virologyen
dc.subjectLymphocytes/*virologyen
dc.subjectMolecular Sequence Dataen
dc.subjectPhylogenyen
dc.subjectPolymerase Chain Reactionen
dc.titleDetection of JC virus type 1 in peripheral lymphocytes, brain and cerebrospinal fluid from two Korean AIDS patients with progressive multifocal leukoencephalopathyen
dc.typeArticleen
dc.contributor.AlternativeAuthor정병훈-
dc.contributor.AlternativeAuthor진재광-
dc.contributor.AlternativeAuthor최은경-
dc.contributor.AlternativeAuthor김경훈-
dc.contributor.AlternativeAuthor최강원-
dc.contributor.AlternativeAuthor오명돈-
dc.contributor.AlternativeAuthor신기철-
dc.contributor.AlternativeAuthor김용선-
dc.identifier.doi10.1159/000063229-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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