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Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors

Cited 41 time in Web of Science Cited 45 time in Scopus
Authors

Choi, S. H.; Yoo, Y.; Yu, J.; Rhee, C.-S.; Min, Y.-G.; Koh, Y. Y.

Issue Date
2007
Publisher
Wiley-Blackwell
Citation
Allergy 2007;62:1051-1056
Keywords
Allergens/adverse effects/immunologyBronchial Hyperreactivity/blood/*epidemiology/immunology/physiopathologyBronchial Provocation TestsImmunoglobulin E/bloodMethacholine Chloride/pharmacologyPrevalenceRespiratoryHypersensitivity/blood/*epidemiology/immunology/physiopathologyRhinitis/blood/*epidemiology/immunology/physiopathologyRisk FactorsSkin Tests
Abstract
BACKGROUND: Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors. METHODS: Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine
ISSN
0105-4538 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17686108

https://hdl.handle.net/10371/12139
DOI
https://doi.org/10.1111/j.1398-9995.2007.01403.x
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