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Development of a novel iron oxide encapsulated prostate-specific membrane antigen (PSMA) targeting nanoparticle as a dual-modality imaging probe for PET and MRI : 전립선특이막항원(PSMA) 표적화 PET과 MRI 이중영상용 신규 산화철 나노입자 프로브 개발
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 정재민 | - |
dc.contributor.author | Sung-Hyun Moon | - |
dc.date.accessioned | 2017-07-14T01:17:37Z | - |
dc.date.available | 2017-07-14T01:17:37Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.other | 000000136103 | - |
dc.identifier.uri | https://hdl.handle.net/10371/121808 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 방사선응용생명과학전공, 2016. 8. 정재민. | - |
dc.description.abstract | I tried to develop a multi-modality imaging probe for PET, MRI and PET/MR by encapsulation with specific amphiphiles using the original one-pot method developed by our study group. In this study, iron oxide (IO) nanoparticles were encapsulated with three amphiphiles containing PEG, DOTA and the prostate-specific membrane antigen (PSMA)-targeting ligand in aqueous medium. The diameter of the prepared nanoparticle DOTA-IO-GUL was 11.01 ± 1.54 nm. DOTA-IO-GUL was labeled with 68Ga in high efficiency. The DOTA-IO-GUL showed a dose-dependent binding to 22Rv1 (PSMA positive) cells via a competitive binding study against 125I-labeled MIP-1072 (PSMA-targeting agent). Additionally, PET and MR imaging results showed PSMA selective uptake by only 22Rv1 (PSMA positive) but not PC-3 (PSMA negative) in dual-tumor xenograft mouse model study. MR imaging showed high resolution, and PET imaging enabled quantification and confirmation of the specificity. In conclusion, I have developed the specific PSMA-targeting IO nanoparticle, DOTA-IO-GUL, as a multi-modality probe for complementary PET, MRI and PET/MR imaging. Additionally I could confirm the reproducibility and scalability of the original one-pot method. | - |
dc.description.tableofcontents | Introduction 1
Materials and Methods 7 Results 28 Discussion 63 References 70 Appendix 79 Abstract in Korean 89 | - |
dc.format | application/pdf | - |
dc.format.extent | 4507243 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Nanoparticle | - |
dc.subject | encapsulation | - |
dc.subject | original one-pot method | - |
dc.subject | Iron Oxide | - |
dc.subject | PET | - |
dc.subject | MRI | - |
dc.subject | PET/MR | - |
dc.subject | prostate cancer | - |
dc.subject | multi-modal | - |
dc.subject.ddc | 616 | - |
dc.title | Development of a novel iron oxide encapsulated prostate-specific membrane antigen (PSMA) targeting nanoparticle as a dual-modality imaging probe for PET and MRI | - |
dc.title.alternative | 전립선특이막항원(PSMA) 표적화 PET과 MRI 이중영상용 신규 산화철 나노입자 프로브 개발 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | 문성현 | - |
dc.description.degree | Doctor | - |
dc.citation.pages | 90 | - |
dc.contributor.affiliation | 의과대학 협동과정 방사선응용생명과학전공 | - |
dc.date.awarded | 2016-08 | - |
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