Publications

Detailed Information

Studies on the role of phosphorylation of alpha-synuclein in alpha-synuclein degradation pathway

DC Field Value Language
dc.contributor.advisor김용식-
dc.contributor.author최희순-
dc.date.accessioned2017-07-14T01:24:30Z-
dc.date.available2017-07-14T01:24:30Z-
dc.date.issued2013-08-
dc.identifier.other000000012931-
dc.identifier.urihttps://hdl.handle.net/10371/121923-
dc.description학위논문 (박사)-- 서울대학교 대학원 : 의학과 약리학 전공, 2013. 8. 김용식.-
dc.description.abstractα-Synuclein (α-SYN) has been characterized as a heat-stable and aggregation-prone protein that can be degraded by both the ubiquitin-proteasomal pathway and the chaperone-lysosomal pathway. However, the switching mechanism between the two pathways is not well understood. In my study, I investigated the increase of the binding of α-SYN to heat shock protein 70 cognate (HSC70) and the lysosomal translocation of α-SYN. Tyrosine phosphorylation at Y136 of α-SYN increased its binding to HSC70. I also found that Y136 phosphorylation of α-SYN can be regulated by the focal adhesion kinase pp125 (FAK) and protein tyrosine phosphatase 1B (PTP1B). Furthermore, a PTP1B inhibitor prevented the accumulation of α-SYN in SH-SY5Y cells by increasing α-SYN translocation into the lysosome, protected dopaminergic neurons against cell death and rescued Rotarod performance in a Parkinsons disease (PD) model. I provide evidence that the regulation of the phosphorylation of α-SYN at Y136 can improve behavioral performance and protect dopaminergic neurons against cell death through enhanced lysosomal degradation of α-SYN.-
dc.description.tableofcontentsAbstract in English i
Contents iii
List of Figures iv
List of Abbreviations vi
Introduction 1
Materials and Methods 5
Results 12
Discussion 44
References 49
Abstract in Korean 58
-
dc.formatapplication/pdf-
dc.format.extent4020590 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectα-synuclein-
dc.subjectproteasome-
dc.subjectlysosome-
dc.subjecttyrosine-
dc.subjectParkinson’s disease-
dc.subjectphosphorylation-
dc.subject.ddc610-
dc.titleStudies on the role of phosphorylation of alpha-synuclein in alpha-synuclein degradation pathway-
dc.typeThesis-
dc.description.degreeDoctor-
dc.citation.pagesvii, 59-
dc.contributor.affiliation의과대학 의학과-
dc.date.awarded2013-08-
Appears in Collections:
Files in This Item:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share