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Studies on characteristics of CD8 T cell response for minor histocompatibility antigen, H60 and role of myeloid cells in the development of t cell response : 부조직적합항원 H60 특이적 CD8 T 세포 반응의 특성과 CD8 T 세포 반응 발달에서 골수계 세포의 역할 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 최은영 | - |
dc.contributor.author | 류수정 | - |
dc.date.accessioned | 2017-07-14T01:44:24Z | - |
dc.date.available | 2017-07-14T01:44:24Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.other | 000000132422 | - |
dc.identifier.uri | https://hdl.handle.net/10371/122301 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과 의과학전공, 2016. 2. 최은영. | - |
dc.description.abstract | The balance between immunity and tolerance is required to maintain immune homeostasis. Understanding how tolerance can be induced extrathymically has important implication for attempts to establish a nonresponsive state to allogeneic antigens borne on tissue grafts and for reestablishing self-tolerance in patients suffering from autoimmune disease. In this study, I investigated whether the induction of help-deficient CD8 T cell response for H60 could generate memory impairment of the H60-specific CD8 T cells and whether the memory impairment of CD8 T cell specific for H60, the most dominant minor H antigen, would influence the immune hierarchy of CD8 T cells specific for other minor H antigens. Helper-deficient CD8 T cells show reduced burst expansion and the tolerance of H60-specific CD8 T cells has rendered CD8 T cells specific for other minor H antigens to be tolerized as well, reducing the total intensity of allo-response induced after transplantation.
To understand the thymic selection process for H60-specific CD8 T cells and control of the specific response, I investigated the effect of a single amino acid substitution in the H60 epitope on the composition of the TCR repertoire. These results demonstrated that some overlap in TCR usage between CD8 T cells responding to H60H vs. H60N stimulation, suggesting that the H60H epitope will be useful for understanding the selection process and control of CD8 T cells specific for H60. In the third part, I showed that differentiation of transplanted Lin- cells into myeloid-derived suppressor cells inflamed skin to be the basis of the alleviation of skin inflammation after Lin- cell transplantation. Taken together, these results provide insight for modeling therapeutic applications to control CD8 T cell response. | - |
dc.description.tableofcontents | Chapter 1 Effects of CD8 T cell tolerance to dominant minor histocompatibility Ag on the memory response and the immune hierarchy in MHC-matched transplantation 1
Introduction 2 Material and Methods 8 Results 11 Discussion 43 Chapter 2 The effect of single amino acid variation on development of H60-reactive CD8 T cell response 46 Introduction 47 Material and Methods 51 Results 55 Discussion 85 Chapter 3 The role myeloid-derived suppressor cells in the skin inflammation model 89 Introduction 90 Material and Methods 95 Results 102 Discussion 138 References 144 Abstract in Korean 150 | - |
dc.format | application/pdf | - |
dc.format.extent | 4379651 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | minor histocompatibility antigen | - |
dc.subject | H60 | - |
dc.subject | immune tolerance | - |
dc.subject.ddc | 610 | - |
dc.title | Studies on characteristics of CD8 T cell response for minor histocompatibility antigen, H60 and role of myeloid cells in the development of t cell response | - |
dc.title.alternative | 부조직적합항원 H60 특이적 CD8 T 세포 반응의 특성과 CD8 T 세포 반응 발달에서 골수계 세포의 역할 연구 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Ryu Sujeong | - |
dc.description.degree | Doctor | - |
dc.citation.pages | vii, 151 | - |
dc.contributor.affiliation | 의과대학 의과학과 | - |
dc.date.awarded | 2016-02 | - |
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