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Studies on characteristics of CD8 T cell response for minor histocompatibility antigen, H60 and role of myeloid cells in the development of t cell response : 부조직적합항원 H60 특이적 CD8 T 세포 반응의 특성과 CD8 T 세포 반응 발달에서 골수계 세포의 역할 연구

DC Field Value Language
dc.contributor.advisor최은영-
dc.contributor.author류수정-
dc.date.accessioned2017-07-14T01:44:24Z-
dc.date.available2017-07-14T01:44:24Z-
dc.date.issued2016-02-
dc.identifier.other000000132422-
dc.identifier.urihttps://hdl.handle.net/10371/122301-
dc.description학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과 의과학전공, 2016. 2. 최은영.-
dc.description.abstractThe balance between immunity and tolerance is required to maintain immune homeostasis. Understanding how tolerance can be induced extrathymically has important implication for attempts to establish a nonresponsive state to allogeneic antigens borne on tissue grafts and for reestablishing self-tolerance in patients suffering from autoimmune disease. In this study, I investigated whether the induction of help-deficient CD8 T cell response for H60 could generate memory impairment of the H60-specific CD8 T cells and whether the memory impairment of CD8 T cell specific for H60, the most dominant minor H antigen, would influence the immune hierarchy of CD8 T cells specific for other minor H antigens. Helper-deficient CD8 T cells show reduced burst expansion and the tolerance of H60-specific CD8 T cells has rendered CD8 T cells specific for other minor H antigens to be tolerized as well, reducing the total intensity of allo-response induced after transplantation.
To understand the thymic selection process for H60-specific CD8 T cells and control of the specific response, I investigated the effect of a single amino acid substitution in the H60 epitope on the composition of the TCR repertoire. These results demonstrated that some overlap in TCR usage between CD8 T cells responding to H60H vs. H60N stimulation, suggesting that the H60H epitope will be useful for understanding the selection process and control of CD8 T cells specific for H60.
In the third part, I showed that differentiation of transplanted Lin- cells into myeloid-derived suppressor cells inflamed skin to be the basis of the alleviation of skin inflammation after Lin- cell transplantation. Taken together, these results provide insight for modeling therapeutic applications to control CD8 T cell response.
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dc.description.tableofcontentsChapter 1 Effects of CD8 T cell tolerance to dominant minor histocompatibility Ag on the memory response and the immune hierarchy in MHC-matched transplantation 1
Introduction 2
Material and Methods 8
Results 11
Discussion 43

Chapter 2 The effect of single amino acid variation on development of H60-reactive CD8 T cell response 46
Introduction 47
Material and Methods 51
Results 55
Discussion 85

Chapter 3 The role myeloid-derived suppressor cells in the skin inflammation model 89
Introduction 90
Material and Methods 95
Results 102
Discussion 138

References 144

Abstract in Korean 150
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dc.formatapplication/pdf-
dc.format.extent4379651 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectminor histocompatibility antigen-
dc.subjectH60-
dc.subjectimmune tolerance-
dc.subject.ddc610-
dc.titleStudies on characteristics of CD8 T cell response for minor histocompatibility antigen, H60 and role of myeloid cells in the development of t cell response-
dc.title.alternative부조직적합항원 H60 특이적 CD8 T 세포 반응의 특성과 CD8 T 세포 반응 발달에서 골수계 세포의 역할 연구-
dc.typeThesis-
dc.contributor.AlternativeAuthorRyu Sujeong-
dc.description.degreeDoctor-
dc.citation.pagesvii, 151-
dc.contributor.affiliation의과대학 의과학과-
dc.date.awarded2016-02-
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