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Barium doped Silica-Titania Hollow Nanoparticles embedded Reduced Graphene Oxide Hydrogel as a Scaffold for Neural Tissue Engineering
바륨 도핑 실리카-티타니아 할로우 나노입자가 도입된 환원그래핀 하이드로겔의 신경조직 스캐폴드로의 응용

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Authors
Heegyeong Yang
Advisor
장정식
Major
공과대학 화학생물공학부
Issue Date
2017-02
Publisher
서울대학교 대학원
Keywords
Neural tissue engineeringRGO hydrogelnanoparticlePC12 celldifferentiationMAPK pathways
Description
학위논문 (석사)-- 서울대학교 대학원 : 화학생물공학부, 2017. 2. 장정식.
Abstract
Three-dimensional RGO based hydrogels (RGO hydrogel, HNP-RGO hydrogel, Ba-HNP-RGO hydrogel) were successfully fabricated and applied as the scaffold for PC12 cells. All the hydrogels had suitable porous structure and elasticity for neurons. In vitro studies, three RGO hydrogels were highly biocompatible and bioactive. PC12 cells easily adhered and proliferated more rapidly on the three RGO hydrogels than glass (negative control). Moreover, RGO based hydrogels facilitated the elongation and branching of primary neurite through activating MAPK pathways. Particularly, the RGO component activated p38 and JNK pathways, while the HNPs component activated ERK and p38 pathways among MAPK pathways. These results would provide the possibilities of RGO based hydrogels for neural tissue engineering and improved understanding about how RGO works on neurons.
Language
English
URI
https://hdl.handle.net/10371/129453
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Theses (Master's Degree_화학생물공학부)
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