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Supplementary Motor Area Epilepsy: From Semiology to Electrophysiology
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- Authors
- Advisor
- Chun Kee Chung
- Major
- 자연과학대학 협동과정뇌과학전공
- Issue Date
- 2017-02
- Publisher
- 서울대학교 대학원
- Keywords
- Supplementary motor area (SMA) ; Epilepsy ; Electroencephalography (EEG) ; Magnetoencephalography (MEG) ; Semiology ; Electrophysiology
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 뇌과학협동과정, 2017. 2. 정천기.
- Abstract
- Introduction: The objective of supplementary motor area (SMA)
epilepsy surgery is complete resection or disconnection of
epileptogenic zone while sustaining the functionally relevant eloquent
cortex. Various diagnostic modalities are used to define the seizure
onset zone and eloquent cortex. However, SMA epilepsy remains
diagnostic challenge due to its location is concealed in mesial frontal
lobe. The clinical characteristics of SMA epilepsy has been described
as an abrupt tonic posturing one or more extremities, vocalization,
without loss of consciousness. Nonetheless, due to preservation of
consciousness, SMA epilepsy can be mistakenly diagnosed.
Moreover, electrophysiological findings are also often misleading
because of interictal spikes found in the midline have normal
background rhythm and paradoxical lateralization. On the other hand,
MEG as the latest neurophysiological tools, has great spatial
resolution and high signal-to-noise ratio which offers several
advantages over EEG in detecting epileptogenic foci in SMA epilepsy.
Therefore in this study, we reevaluate presurgical diagnostic
modalities and sought to find clinical value of MEG to localize
epileptogenic zone in SMA epilepsy. Moreover, lateralizing value of
semiology observed in patient group will also be determined.
Methods: Forty-four patients who underwent epilepsy respective
surgery and had SMA removed were reviewed retrospectively.
Clinical characteristics of each patients were assessed and its
lateralizing value were calculated. Concordance of interictal VEM,
PET, ictal SPECT, and MRI results to resection area were evaluated
and related them to surgical outcome. Interictal spikes source
ii
distribution in simultaneous EEG/MEG were done by using sLORETA
separately to compare EEG and MEG sensitivity.
Results: The most reliable predictors of seizure lateralization were
versive head movement and unilateral tonic posturing (p=0.004 and
p=0.021, respectively), indicating contralateral lateralization in more
than 90% of patients. Only interictal MEG significantly localized
correctly in 7 of 9 patients with favorable outcome (p=0.021) and
none of the non-favorable outcome patients showed abnormalities
localized in epileptogenic lobe. In simultaneous EEG/MEG, 4 of 7
favorable outcome patients showed non-lateralizing interictal EEG,
while 6 of 7 favorable outcome patients showed localized interictal
MEG within resection area. One patient had MRI revealed tumor
lesion in right SMA and also left hippocampal sclerosis, exclusively
had interictal EEG spikes that constantly located in temporal lobe
while interictal MEG spikes predominantly localized within resection
area.
Conclusion: MEG is a useful tool in localizing epileptogenic zone,
especially when EEG fails to localize or lateralize epileptogenic lesion
in the midline area, such in SMA epilepsy case.
Keyword: Supplementary motor area (SMA), Epilepsy,
Electroencephalography (EEG), Magnetoencephalography (MEG),
Semiology, Electrophysiology
Student Number: 2014-25244
- Language
- English
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