Identification of secondary metabolites from the marine plant and bacteria

Abstract

The marine environment has established to be a very rich source of particularly potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy and anti-viral assays. The chemical inquiry of several marine plant and bacteria with the isolation and structure elucidation of secondary metabolites with biological activities are described in this thesis. Actinobacteria from Rayong beach, Thailand, Streptomycetes sp., let us the isolation of new compound with naphthalene moiety. The structure was elucidated by extensive spectroscopic data (IR, MS, 1H and 13C NMR, COSY, HSQC, HMBC) analysis. Continuous research on marine derived bacteria led to collections of a number of actinomycetes. Actinobacteria from the mud flat, streptomyces sodiiphilus, let us the isolation of butanamide. 1D and 2D NMR study revealed the moiety, which is common to natural products. It is reported alkaliphilic actinomycetes that its secondary metabolites able of quenching quorum sensing controlled behaviors in gram-negative reporter strains. A collection of the marine plant Peucedanum japonicum (Umbelliferae) from the south of Korea beach, led to the isolation of the five novel khellactone.