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Effect of Hydroxychloroquine Treatment on Dry Eyes in subjects with Primary Sjögren's Syndrome: double blind randomized control study : 1차 쇼그렌 증후군 환자의 건성안에 대한 Hydroxychloroquine의 치료 효과: 이중맹검 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김미금 | - |
dc.contributor.author | Chang Ho Yoon | - |
dc.date.accessioned | 2017-07-19T10:12:49Z | - |
dc.date.available | 2017-07-19T10:12:49Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.other | 000000017658 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132420 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2014. 2. 김미금. | - |
dc.description.abstract | Introduction: Effect of hydroxychloroquine (HCQ) on dry eye has not been fully determined yet. This study was aimed to compare the 12-weeks efficacy of HCQ medication with placebo in the management of dry eye in Primary Sjögren's Syndrome (pSS).
Methods: A double-blind, randomised control study was conducted in 39 subjects of 153 pSS subjects from May 2011 through August 2013. The diagnosis of Sjögren's syndrome was made on the basis of the classification criteria of the American-European Consensus Group. Subjects received 300 mg HCQ or placebo once daily for 12 weeks. Subjects were evaluated at baseline, 6 weeks and 12 weeks and re-visited at 16 weeks after drug discontinuance. Fluorescein staining score, Schirmer test score, tear film break-up time (TBUT), and ocular surface disease index (OSDI) were measured, and tears and blood were collected for ESR, IL-6, IL-17, B-cell activating factor (BAFF) and Th17 cell analysis. Color test and fundus were examined to monitor HCQ complications. Results: Twenty-six subjects completed follow-ups. Fluorescein staining score and Schirmer test score did not differ significantly. The OSDI improved with medication, but this was not insignificant between the groups. TBUT, Serum IL-6, ESR, serum and tear BAFF, and the proportion of Th17 cells did not change in either group. Conclusions: HCQ at 300 mg daily has no apparent clinical benefit on dry eye and systemic inflammation in pSS. | - |
dc.description.tableofcontents | TABLE OF CONTENTS
I. Introduction -----------------------------------------1 II. Patients and methods 1. Patients -------------------------------------------3 2. Treatment protocol ---------------------------------6 3. Tear sample collection -----------------------------8 4. Measurement of tear and serum cytokine profiles ----8 5. Flow cytometric analysis for Th17 cells -------------9 6. Sample size calculations --------------------------11 7. Statistical analysis --------------------------------11 III. Results 1. General complications of the subjects and characteristics of drop-out subjects ------------------ 13 2. Characteristics of the study population at baseline ---13 3. Changes in the parameters -------------------------14 IV. Discussion ----------------------------------------18 V. Acknowledgement ----------------------------------23 VI. References ----------------------------------------24 VII. 국문초록 ------------------------------------------28 LISTS of TABLE and FIGURES Table 1. Demographics and initial characteristics of the subjects --------15 Table 2. Changes of the parameters between the HCQ and placebo groups during follow-up -----------------------------------------------------------16 Figure 1. A double-blind randomized control study was conducted in 39 subjects of 153 pSS subjects who visited an eye clinic from May 2011 through August 2013. ----------------------------------------------------------------5 Figure 2. Corneal fluorescein staining score using the National Eye Institute scale (on a scale of 0–15) in a primary Sjögrens syndrome subject ----------------------------------------------------------------------------------7 Figure 3. Schematic design of the study protocol regarding time-dependent treatment and examinations -----------------------------------------7 Figure 4. Flow cytometric analysis of Th17 cells -----------------------------10 | - |
dc.format | application/pdf | - |
dc.format.extent | 1370866 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Hydroxychloroquine | - |
dc.subject | Sjögren's Syndrome | - |
dc.subject | Double blind randomized prospective study | - |
dc.subject | OSDI | - |
dc.subject.ddc | 610 | - |
dc.title | Effect of Hydroxychloroquine Treatment on Dry Eyes in subjects with Primary Sjögren's Syndrome: double blind randomized control study | - |
dc.title.alternative | 1차 쇼그렌 증후군 환자의 건성안에 대한 Hydroxychloroquine의 치료 효과: 이중맹검 연구 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | 윤창호 | - |
dc.description.degree | Master | - |
dc.citation.pages | XXIX, 29 | - |
dc.contributor.affiliation | 의과대학 임상의과학과 | - |
dc.date.awarded | 2014-02 | - |
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