S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Theses (Master's Degree_의학과)
Effects of zileuton, a 5-Lipoxygenase inhibitor, in experimental intracranial hemorrhage
5-지방산화효소 억제제 질루톤의 뇌출혈 모델에서의 영향 연구
- 의과대학 의학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 의학과 중개의학 전공, 2016. 2. 이상건.
- The 5-lipoxygenase is a key enzyme involved in the biosynthesis of leukotrienes and its inhibition showed neuroprotective effects in various models of central nervous system diseases such as cerebral ischemia, epilepsy, and Alzheimers disease. In this study, we investigate whether zileuton, administered after intracerebral hemorrhage (ICH), can reduce cerebral edema and hemorrhage volume in a rodent experimental model of ICH. ICH was induced via stereotactic administration of bacterial collagenase in Sprague-Dawley rats. Edema was calculated as the increased amount of water content of the cerebral hemisphere compared to that of the cerebellum, Hemorrhage size was quantified by a spectrophotometric assay. Edema was reduced in the double-dose group compared to the ICH-only group (3.50±0.17% vs. 5.22±0.37%
p=0.008). The administration of zileuton did not show a change in hemorrhage size (p=0.548). These results show zileuton treatment may have neuroprotective effects after ICH through reduction of perihematomal edema.