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Therapy-related acute myeloid leukemia after the treatment of primary solid cancer in children : 소아 고형 종양 치료 후 발생한 치료 연관 급성 골수성 백혈병
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 신희영 | - |
dc.contributor.author | 홍경택 | - |
dc.date.accessioned | 2017-07-19T10:35:52Z | - |
dc.date.available | 2017-07-19T10:35:52Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.other | 000000140785 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132909 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2017. 2. 신희영. | - |
dc.description.abstract | Therapy-related acute myeloid leukemia (t-AML) or therapy-related myelodysplastic syndrome (t-MDS) has a dismal prognosis and is one of the second malignant neoplasms, which could be encountered by pediatric oncologist more frequently. We have reviewed our experience with pediatric t-AML/t-MDS during a 17-year period.
Between October 2000 and September 2016, 16 patients who had primary solid tumors were diagnosed with t-AML at the Seoul National University Childrens Hospital. The primary solid tumors assessed included osteosarcoma (n=5), neuroblastoma (n=2), Wilms tumor (n=2), Ewing sarcoma (n=2), medulloblastoma (n=1), pineoblastoma (n=2), rhabdomyosarcoma (n=1), anaplastic ependymoma (n=1), and a malignant germ cell tumor (n=1). The median patient age at the time of diagnosis of the primary solid tumors was 9.6 years (range, 0.1–15.4 years), and the median age at the time of diagnosis of t-AML was 14.0 years (range, 4.7–23.9 years). The crude estimated incidence rate of t-AML from pediatric primary solid cancer was 0.78%. The median latency period from the end of the primary tumor treatment to the diagnosis of t-AML/t-MDS was 29 months (range, 6–130 months). Fifteen patients received induction chemotherapy after the diagnosis of t-AML. Among them, only 12 patients achieved complete remission (CR). Of the 12 patients who achieved CR, only 7 patients underwent hematopoietic stem cell transplantation (HSCT). The 3-year and 5-year overall survival (OS) rates were 33.7 ± 12.2% and 25.2 ± 11.7%, respectively, and the 3-year and 5-year event-free survival rates were 26.9 ± 11.5% and 20.2 ± 10.4%, respectively. The patients who underwent HSCT showed favorable 5-year OS rates (57.1 ± 18.7%), while the 5-year OS rates of those who did not undergo HSCT was 0%. This study demonstrated that an achievement of CR and a subsequent HSCT can be the optimum solution for the treatment of t-AML, and this strategy showed an acceptable outcome. Screening patients who are susceptible to t-AML and preventing them from developing t-AML will be required in the future. | - |
dc.description.tableofcontents | Introduction 1
Materials and Methods 3 Patient 3 Data collection 3 Chemotherapy regimen 4 Statistical methods 5 Results 6 Characteristics of the patients and t-AML 6 Estimated incidence rate of t-AML 8 Treatment of t-AML and the outcome 8 Overall and event-free survival 9 Comparison of t-AML and de novo AML 9 Discussion 19 References 22 Abstract in Korean 26 | - |
dc.format | application/pdf | - |
dc.format.extent | 328071 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | therapy-related acute myeloid leukemia | - |
dc.subject | therapy-related myelodysplastic syndrome | - |
dc.subject | pediatric | - |
dc.subject | hematopoietic stem cell transplantation | - |
dc.subject | solid tumor | - |
dc.subject.ddc | 610 | - |
dc.title | Therapy-related acute myeloid leukemia after the treatment of primary solid cancer in children | - |
dc.title.alternative | 소아 고형 종양 치료 후 발생한 치료 연관 급성 골수성 백혈병 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Kyung Taek Hong | - |
dc.description.degree | Master | - |
dc.citation.pages | 27 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2017-02 | - |
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