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Suppressive effect of Schisandrin B on TGFβ1-induced NF-κB activation in vascular smooth muscle cells

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Authors

김재경

Advisor
전주홍
Major
의과대학 의과학과
Issue Date
2013-02
Publisher
서울대학교 대학원
Description
학위논문 (석사)-- 서울대학교 대학원 : 의과학과 의과학 전공, 2013. 2. 전주홍.
Abstract
TGF β1 is involved in the pathogenesis of vascular diseases through modulating various signaling pathways including NF-κB. Schisandra chinensis (S. chinensis) extract, which is as an oriental herbal medicine, shows beneficial effects on various vascular diseases that are caused by abnormal TGFβ1 signaling. In this study, I found that S. chinensis extract inhibits TGFβ1-induced NF-κB activation in A7r5 vascular smooth muscle cells (VSMCs). Among the active ingredients of S. chinensis extract, Schisandrin B most potently suppressed TGFβ1-induced IKKα/β phosphorylation, IκBα phosphorylation and degradation, and p65 translocation into the nucleus. These pharmacologic actions of Schisandrin B were found to be independent of SMAD signaling. This result may useful to understand the molecular mechanisms that underlie TGFβ1-induced NF-κB signaling pathway. In addition, this study may help understanding vascular pathogenesis induced by aberrant TGF β1
Language
English
URI
https://hdl.handle.net/10371/132979
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