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Differential roles of Kv4.1 and Kv4.2 channels in excitatory postsynaptic responses in the hippocampus : 해마 신경세포의 흥분성 후시냅스 반응에 대한 Kv4.1과 Kv4.2 채널의 차별적인 역할
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 호원경 | - |
dc.contributor.author | 권민정 | - |
dc.date.accessioned | 2017-07-19T10:41:59Z | - |
dc.date.available | 2017-07-19T10:41:59Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.other | 000000141958 | - |
dc.identifier.uri | https://hdl.handle.net/10371/133022 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2017. 2. 호원경. | - |
dc.description.abstract | A-type K+ channel is important in the integration of subthreshold synaptic potentials and it is suggested that signaling mechanisms by regulation of A-type K+ channel could profoundly influence neuronal excitability. Among the Kv4 family, the intrinsic property of Kv4.1 and Kv4.2 channels are widely studied. Until today, however, the contribution of A-type K+ channel in synaptic plasticity remains unknown.
The effectiveness of inhibition of K+ channel in synaptic modification is compared in DG and CA1. 50 Hz train stimulus applied either perforant path-DG granule cell or Schaffer collateral-CA1 pyramidal cell pathways. I observed synaptic response by using an antibody to Kv4.1/Kv4.2 and found that Kv4.2 channel has the correlation with synaptic plasticity. My data demonstrates that inhibition of Kv4.2 induce enhancement with synaptic plasticity, whereas an anti-Kv4.1 antibody does not affect. This form of plasticity is different from the general long-term plasticity which was studied before. The mechanisms underlying the effect on synaptic plasticity were investigated. It was observed that NMDA receptor blocker, APV, partially blocked potentiation in DG. However, a complete blockade of the potentiation occurred when nimodipine (L-type voltage-gated Ca2+ channel antagonist) was applied. In addition, PKC plays a crucial role in intracellular signaling cascades and its mechanisms thought to be involved in synaptic plasticity. My results support the evidence of distinct density and distribution about Kv4.1 / Kv4.2 in DG and CA1 of the hippocampus. Furthermore, in this study, I clearly show that that synaptic plasticity that associated with Kv4.2 which is distinct from general synaptic plasticity and its mechanism. | - |
dc.description.tableofcontents | Introduction 1
Materials and Methods 4 Results 7 Discussion 37 References 41 Abstract in Korean 45 | - |
dc.format | application/pdf | - |
dc.format.extent | 2001486 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | A-type K+ current | - |
dc.subject | Kv4.1 | - |
dc.subject | Kv4.2 | - |
dc.subject | synaptic plasticity | - |
dc.subject | Long-term potentiation (LTP) | - |
dc.subject | DG granule cells | - |
dc.subject | CA1 pyramidal cells | - |
dc.subject.ddc | 610 | - |
dc.title | Differential roles of Kv4.1 and Kv4.2 channels in excitatory postsynaptic responses in the hippocampus | - |
dc.title.alternative | 해마 신경세포의 흥분성 후시냅스 반응에 대한 Kv4.1과 Kv4.2 채널의 차별적인 역할 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Min Jeong Kwon | - |
dc.description.degree | Master | - |
dc.citation.pages | 46 | - |
dc.contributor.affiliation | 의과대학 의과학과 | - |
dc.date.awarded | 2017-02 | - |
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