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STAT3 Stabilizes C/EBPβ in H-Ras Transformed Mammary Epithelial Cells : 인체유방상피세포에서 STAT3에의한 C/EBPβ 안정화
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 서영준 | - |
dc.contributor.author | 이릴리 | - |
dc.date.accessioned | 2017-07-19T11:20:24Z | - |
dc.date.available | 2017-07-19T11:20:24Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.other | 000000026355 | - |
dc.identifier.uri | https://hdl.handle.net/10371/133577 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2015. 2. 서영준. | - |
dc.description.abstract | STAT3 (Signal transducer and activator of transcription 3) plays important roles in cancer-related inflammation by controlling expression of pro-inflammatory cytokines and chemokines. Recent studies suggest STAT3 and C/EBPβ (CCAAT-enhancer binding protein beta) synergistically increase cancer cell proliferation and epithelial-mesenchyml transition (EMT) in breast and brain cancer respectively. C/EBPβ is a leucine-zipper transcription factor that regulates expression of a variety of inflammatory cytokines or chemokines, such as IL-8, G-CSF (granulocyte colony stimulating factor), and GM-CSF (granulocyte macrophage colony stimulating factor) which induce neutrophil infiltration and differentiation. However, the molecular mechanism by which STAT3 and C/EBPβ cooperatively interact has not been fully elucidated. In this study, I found that the level of C/EBPβ protein but not that of its mRNA transcript was decreased in the absence of STAT3 in H-Ras MCF10A cells. In addition, silencing STAT3 dramatically induced proteasomal degradation of C/EBPβ and thus suppressed transcription of C/EBPβ target genes. Furthermore, direct interaction between STAT3 and C/EBPβ was confirmed by immuno-precipitation. Taken together, STAT3 stabilizes C/EBPβ thereby promoting cancer-associated inflammation. | - |
dc.description.tableofcontents | Abstract ............................. i
Contents ............................iii List of Figures..................... iv Introduction......................... 1 Materials and Methods......... 3 Results .............................. 9 Discussion ........................28 References........................ 31 Abstract in Korean | - |
dc.format | application/pdf | - |
dc.format.extent | 1803289 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | STAT3 | - |
dc.subject | C/EBPβ | - |
dc.subject | Cancer-associated inflammation | - |
dc.subject | H-Ras MCF10A | - |
dc.subject.ddc | 615 | - |
dc.title | STAT3 Stabilizes C/EBPβ in H-Ras Transformed Mammary Epithelial Cells | - |
dc.title.alternative | 인체유방상피세포에서 STAT3에의한 C/EBPβ 안정화 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Lil-Li Lee | - |
dc.description.degree | Master | - |
dc.citation.pages | 33 | - |
dc.contributor.affiliation | 약학대학 약학과 | - |
dc.date.awarded | 2015-02 | - |
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