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STAT3 Stabilizes C/EBPβ in H-Ras Transformed Mammary Epithelial Cells : 인체유방상피세포에서 STAT3에의한 C/EBPβ 안정화

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dc.contributor.advisor서영준-
dc.contributor.author이릴리-
dc.date.accessioned2017-07-19T11:20:24Z-
dc.date.available2017-07-19T11:20:24Z-
dc.date.issued2015-02-
dc.identifier.other000000026355-
dc.identifier.urihttps://hdl.handle.net/10371/133577-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2015. 2. 서영준.-
dc.description.abstractSTAT3 (Signal transducer and activator of transcription 3) plays important roles in cancer-related inflammation by controlling expression of pro-inflammatory cytokines and chemokines. Recent studies suggest STAT3 and C/EBPβ (CCAAT-enhancer binding protein beta) synergistically increase cancer cell proliferation and epithelial-mesenchyml transition (EMT) in breast and brain cancer respectively. C/EBPβ is a leucine-zipper transcription factor that regulates expression of a variety of inflammatory cytokines or chemokines, such as IL-8, G-CSF (granulocyte colony stimulating factor), and GM-CSF (granulocyte macrophage colony stimulating factor) which induce neutrophil infiltration and differentiation. However, the molecular mechanism by which STAT3 and C/EBPβ cooperatively interact has not been fully elucidated. In this study, I found that the level of C/EBPβ protein but not that of its mRNA transcript was decreased in the absence of STAT3 in H-Ras MCF10A cells. In addition, silencing STAT3 dramatically induced proteasomal degradation of C/EBPβ and thus suppressed transcription of C/EBPβ target genes. Furthermore, direct interaction between STAT3 and C/EBPβ was confirmed by immuno-precipitation. Taken together, STAT3 stabilizes C/EBPβ thereby promoting cancer-associated inflammation.-
dc.description.tableofcontentsAbstract ............................. i
Contents ............................iii
List of Figures..................... iv
Introduction......................... 1
Materials and Methods......... 3
Results .............................. 9
Discussion ........................28
References........................ 31
Abstract in Korean
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dc.formatapplication/pdf-
dc.format.extent1803289 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectSTAT3-
dc.subjectC/EBPβ-
dc.subjectCancer-associated inflammation-
dc.subjectH-Ras MCF10A-
dc.subject.ddc615-
dc.titleSTAT3 Stabilizes C/EBPβ in H-Ras Transformed Mammary Epithelial Cells-
dc.title.alternative인체유방상피세포에서 STAT3에의한 C/EBPβ 안정화-
dc.typeThesis-
dc.contributor.AlternativeAuthorLil-Li Lee-
dc.description.degreeMaster-
dc.citation.pages33-
dc.contributor.affiliation약학대학 약학과-
dc.date.awarded2015-02-
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