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Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hyun-Jai | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Park, Kyung-Woo | - |
dc.contributor.author | Ju, Jae-Ran | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Lee, Myoung-Mook | - |
dc.contributor.author | Park, Young-Bae | - |
dc.date.accessioned | 2009-11-18T07:41:30Z | - |
dc.date.available | 2009-11-18T07:41:30Z | - |
dc.date.issued | 2002-03-28 | - |
dc.identifier.citation | J Hum Genet. 2002;47(2):88-91. | en |
dc.identifier.govdoc | http://dx.doi.org/10.1007/s100380200006 | - |
dc.identifier.issn | 1434-5161 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11916008 | - |
dc.identifier.uri | https://hdl.handle.net/10371/13361 | - |
dc.description.abstract | The matrix metalloproteinases appear to play an important role in the development and progression of atherosclerotic lesions. We studied the C-1562T polymorphism of the gelatinase B promoter in relation to coronary artery disease and restenosis after a percutaneous coronary intervention (PCI) in Koreans. To determine the frequency of the C-1562T allele, we examined 63 patients with coronary artery disease who underwent both PCI and 6-month follow-up coronary angiograms (CAGs), and 67 control patients with a normal CAG with respect to their clinical data and genotype. Frequencies of the C/C homozygotes and the non-C/C heterozygotes and homozygotes (C/T and T/T) were 94% and 6% in the normal CAG group, and 76.2% and 23.8% in the patient group, respectively. This gave a relative risk of 0.203 (95% CI: 0.063-0.651, P = 0.005) for coronary artery disease when the C/C genotype was compared with the non-C/C genotype. In the patient groups, the allele frequencies of the C/C and non-C/C were 80% and 20% in the nonrestenotic subgroup, and 71.4% and 28.6% in the restenotic subgroup (P = 0.554). No T/T homozygote was found in any of the groups. We conclude that C/C homozygosity is a potential genetic protective factor for coronary artery disease in Koreans. | en |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | en |
dc.subject | Coronary Artery Disease/enzymology/*genetics | en |
dc.subject | Coronary Restenosis/enzymology/*genetics | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Matrix Metalloproteinase 9/*genetics/metabolism | en |
dc.subject | Middle Aged | en |
dc.subject | Promoter Regions, Genetic/*genetics | en |
dc.subject | Angioplasty, Transluminal, Percutaneous Coronary | - |
dc.subject | Polymorphism, Genetic | - |
dc.title | Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조현재 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 박경우 | - |
dc.contributor.AlternativeAuthor | 주재란 | - |
dc.contributor.AlternativeAuthor | 오세일 | - |
dc.contributor.AlternativeAuthor | 이명묵 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
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