Browse

High concentration of paclitaxel coated graft for hemodialysis elicits a severe foreign body response in a porcine model

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
신지혜
Advisor
박종상
Major
자연과학대학 화학부
Issue Date
2016-08
Publisher
서울대학교 대학원
Keywords
PaclitaxelAV graftneointimal hyperplasiaforeign body responsepatencyhemodialysis
Description
학위논문 (석사)-- 서울대학교 대학원 : 화학부, 2016. 8. 박종상.
Abstract
The most crucial reason for vascular access dysfunction in hemodialysis patients is stenosis caused by neointimal hyperplasia. Until now, paclitaxel has been shown to act as a great anti-proliferative agent and effectively lowers stenosis on graft-venous anastomosis sites. Dipping method allows us to obtain paclitaxel coated Arteriovenous (AV) expanded polytetrafluoroethylene (ePTFE) grafts in a quick, uniform and facile manner. As the whole graft surface elutes paclitaxel upon implantation by systemic circulation, I ought to validate how various amounts of paclitaxel release affect a porcine system. I coated the following concentrations of paclitaxel for study- Control (0 ug/mm2), Group 1 (0.14ug/mm2), Group 2 (0.28ug/mm2), Group 3 (0.51ug/mm2), Group4 (1.11ug/mm2), and Group 5 (2.22ug/mm2). This work uncovers that in general, paclitaxel coated grafts revealed high level of patency compared to the control group in which grafts were almost all occluded, however
at high concentrations of paclitaxel, the surrounding tissue and the graft retained little affinity. I attribute this for a foreign body response and hence arise necessity to tune the amount of paclitaxel in order to minimize both stenosis and foreign body response.
Language
English
URI
http://hdl.handle.net/10371/134938
Files in This Item:
Appears in Collections:
College of Humanities (인문대학)Korean Language and Literature (국어국문학과)Others_국어국문학과
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse