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Proteome analysis of human amnion and amniotic fluid by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Soo-Jin | - |
dc.contributor.author | Yoon, Won-Gap | - |
dc.contributor.author | Song, Jin-Su | - |
dc.contributor.author | Jung, Hyun Sook | - |
dc.contributor.author | Kim, Chong Jai | - |
dc.contributor.author | Oh, Soo Young | - |
dc.contributor.author | Yoon, Bo Hyun | - |
dc.contributor.author | Jung, Guhung | - |
dc.contributor.author | Kim, Hie-Joon | - |
dc.contributor.author | Nirasawa, Takashi | - |
dc.date.accessioned | 2009-11-18T08:58:31Z | - |
dc.date.available | 2009-11-18T08:58:31Z | - |
dc.date.issued | 2005-11-19 | - |
dc.identifier.citation | Proteomics. 2006 Jan;6(1):349-63. | en |
dc.identifier.issn | 1615-9853 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16294308 | - |
dc.identifier.uri | https://hdl.handle.net/10371/13502 | - |
dc.description.abstract | Proteome analysis by 2-DE and PMF by MALDI-TOF MS was performed on human amnion and amniotic fluid at term. Ninety-two soluble and nineteen membrane proteins were identified from amnion. Thirty-five proteins were identified from amniotic fluid. Calgranulin A and B were found in all patients infected with Ureaplasma urealyticum, but not in any of the patients without infection, indicating that they are potential markers of intrauterine infection. Identity of calgranulin A and B was confirmed by MALDI-TOF/TOF MS. This study represents the first extensive analysis of the human amnion and amniotic fluid proteome at term and demonstrates that 2-DE and MALDI-TOF MS is a useful tool for identifying clinically significant biomarkers of problematic pregnancies. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Amino Acid Sequence | en |
dc.subject | Amnion/*chemistry | en |
dc.subject | Amniotic Fluid/*chemistry | en |
dc.subject | Base Sequence | en |
dc.subject | Calgranulin A/isolation & purification | en |
dc.subject | Calgranulin B/chemistry/isolation & purification | en |
dc.subject | DNA Primers | en |
dc.subject | Electrophoresis, Gel, Two-Dimensional/*methods | en |
dc.subject | Humans | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods | en |
dc.subject | Ureaplasma Infections/metabolism | en |
dc.subject | Proteome | - |
dc.title | Proteome analysis of human amnion and amniotic fluid by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박수진 | - |
dc.contributor.AlternativeAuthor | 윤원갑 | - |
dc.contributor.AlternativeAuthor | 송진수 | - |
dc.contributor.AlternativeAuthor | 정현숙 | - |
dc.contributor.AlternativeAuthor | 김종재 | - |
dc.contributor.AlternativeAuthor | 오수영 | - |
dc.contributor.AlternativeAuthor | 윤보현 | - |
dc.contributor.AlternativeAuthor | 정구홍 | - |
dc.contributor.AlternativeAuthor | 김희준 | - |
dc.identifier.doi | 10.1002/pmic.200500084 | - |
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