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Transcriptomics and methylomics in chronic periodontitis with tobacco use: a pilot study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Young-Dan | - |
dc.contributor.author | Kim, Pil-Jong | - |
dc.contributor.author | Kim, Hong-Gee | - |
dc.contributor.author | Seol, Yang-Jo | - |
dc.contributor.author | Lee, Yong-Moo | - |
dc.contributor.author | Ku, Young | - |
dc.contributor.author | Rhyu, In-Chul | - |
dc.contributor.author | Ryoo, Hyun-Mo | - |
dc.date.accessioned | 2017-10-31T04:38:15Z | - |
dc.date.available | 2017-10-31T14:01:24Z | - |
dc.date.issued | 2017-08-10 | - |
dc.identifier.citation | Clinical Epigenetics, 9(1):81 | ko_KR |
dc.identifier.issn | 1868-7083 | - |
dc.identifier.uri | https://hdl.handle.net/10371/137258 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | ko_KR |
dc.description.abstract | Abstract
Background Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the role of smoking in the development and progress of periodontal disease. In this study, we performed transcriptomic and methylomic analyses of non-periodontitis and periodontitis-affected gingival tissues according to smoking status. Methods Human gingival tissues were obtained from 20 patients, including non-smokers with and without periodontitis (n=5 per group) and smokers with and without periodontitis (n=5 per group). Total RNA and genomic DNA were isolated, and their quality was validated according to strict standards. The Illumina NextSeq500 sequencing system was used to generate transcriptome and methylome datasets. Results Comprehensive analysis, including between-group correlation, differential gene expression, DNA methylation, gene set enrichment, and protein-protein interaction, indicated that smoking may change the transcription and methylation states of extracellular matrix (ECM) organization-related genes, which exacerbated the periodontal condition. Conclusions Our results suggest that smoking-related changes in DNA methylation patterns and subsequent alterations in the expression of genes coding for ECM components may be causally related to the increased susceptibility to periodontitis in smokers as they could influence ECM organization, which in turn may have an effect on disease characteristics. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | DNA methylation | ko_KR |
dc.subject | Epigenomics | ko_KR |
dc.subject | Extracellular matrix | ko_KR |
dc.subject | Periodontal disease | ko_KR |
dc.subject | Smoking | ko_KR |
dc.subject | Transcriptome | ko_KR |
dc.title | Transcriptomics and methylomics in chronic periodontitis with tobacco use: a pilot study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조영단 | - |
dc.contributor.AlternativeAuthor | 김필종 | - |
dc.contributor.AlternativeAuthor | 김홍기 | - |
dc.contributor.AlternativeAuthor | 설양조 | - |
dc.contributor.AlternativeAuthor | 이용무 | - |
dc.contributor.AlternativeAuthor | 구영 | - |
dc.contributor.AlternativeAuthor | 류인철 | - |
dc.contributor.AlternativeAuthor | 류현모 | - |
dc.identifier.doi | 10.1186/s13148-017-0381-z | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-10-03T16:45:09Z | - |
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