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Magnetic Nanoparticles Embedded Silver Nanoshell as Highly Sensitive SERS Probe : 자성나노입자를 포함한 은 나노쉘의 합성과 민감한 표면증강 라만산란 프로브로서의 응용

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dc.contributor.advisor이윤식-
dc.contributor.author박소연-
dc.date.accessioned2017-10-31T07:42:50Z-
dc.date.available2017-10-31T07:42:50Z-
dc.date.issued2017-08-
dc.identifier.other000000145931-
dc.identifier.urihttps://hdl.handle.net/10371/137466-
dc.description학위논문 (석사)-- 서울대학교 대학원 공과대학 화학생물공학부, 2017. 8. 이윤식.-
dc.description.abstractSERS (Surface-enhanced Raman scattering) is an efficient tool for multiplexed analysis of various targets because it has unique signal patterns with narrow band width and is stable to photo-bleaching. The structure of metal substrate is very important in obtaining strong SERS signals. So far, various approaches have been tried to develop new types of metal substrate for sensitive detection of targets at low concentration. In this thesis, a new type of SERS nanoprobe was synthesized which has hundreds of iron oxide magnetic nanoparticles at the core part, and silver shell at the outer part. (Magnetic silver
Nanoshell, M AgNS) The surface of silver shell has bumpy structure, which could lead to the formation of hot spots, affording strong SERS signal. Besides, SERS signal could be further intensified by magnetic-induced aggregation. Through this M AgNS nanoprobe, 4-fluorothiophenol (4-FBT) was detected at low concentration as 1 μM, which corresponds to 16 ppb. Thiram and malathion, which are mainly used pesticides in the farm, were also detected at low concentrations using the aggregated M AgNS. The limit of detection (LOD) for thiram was 10 μM, which corresponds to 3 ppm. M AgNS nanoprobe is expected to be utilized in on-site detection of various analytes at low concentrations using a 785 nm portable Raman system.
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dc.description.tableofcontentsI. Introduction 1
I. 1 The Advantages of SERS 1
I. 2 The importance of Hot Spot for SERS signal enhancement 5
I. 3 SERS technique for molecular detection 10
I. 4 Research Objectives 12
II. Experimental Section 13
II. 1 Chemicals and Materials 13
II. 2 Instruments 14
II. 3 Preparation of catechol-functionalized silica NPs 15
II. 4 Preparation of PVP-coated Fe3O4 NPs 16
II. 5 Preparation of magnetic silica NPs (M silica NPs) 17
II. 6 Preparation of magnetic silver nanoshell (M AgNS) 18
II. 7 Detection processes of chemicals with M AgNS 19
II. 8 SERS measurement via M AgNS aggregation by a magnet 20
II. 9 The effect of Hot spots of M AgNSs on SERS sensitivity 21
III. Results and Discussion. 22
III .1 Preparation of M AgNSs 22
III. 2 Characterization of M AgNSs 24
III. 3 SERS spectra of 4-FBT on M AgNSs before and after aggregation by a magnet 28
III. 4 SERS spectra of 4FBT at various concentrations with M AgNS 30
III. 5 SERS measurement of thiram, malathion on M AgNSs 32
III. 6 The effect of Hot spots of M AgNSs on SERS sensitivity 35
IV. Conclusion 40
V. References 41
Abstract in Korean 45
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dc.formatapplication/pdf-
dc.format.extent1191088 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectSurface enhanced Raman scattering-
dc.subjectsilver nanoshell-
dc.subjectmagnetic induced aggregation-
dc.subjectmolecular detection-
dc.subject.ddc660.6-
dc.titleMagnetic Nanoparticles Embedded Silver Nanoshell as Highly Sensitive SERS Probe-
dc.title.alternative자성나노입자를 포함한 은 나노쉘의 합성과 민감한 표면증강 라만산란 프로브로서의 응용-
dc.typeThesis-
dc.description.degreeMaster-
dc.contributor.affiliation공과대학 화학생물공학부-
dc.date.awarded2017-08-
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