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Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Yu, Nam-Kyung; Uhm, Heesoo; Shim, Jaehoon; Choi, Jun-Hyeok; Bae, Sangsu; Sacktor, Todd Charlton; Hohng, Sungchul; Kaang, Bong-Kiun
Issue Date
2017-11-29
Publisher
BioMed Central
Citation
Molecular Brain, 10(1):56
Keywords
PKMζPKM-zetaAMPARQuantum dotsSingle molecule imagingGluA2LTPLateral diffusion
Abstract
Abstract
Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its overexpression enhances long-term memory and LTP. Thus, multiple lines of evidence suggest a significant role for persistently elevated PKMζ levels in long-term memory. The molecular mechanisms of how synaptic properties are regulated by the increase in PKMζ, however, are still largely unknown. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR) mediates most of the fast glutamatergic synaptic transmission in the brain and is known to be critical for the expression of synaptic plasticity and memory. Importance of AMPAR trafficking has been implicated in PKMζ-mediated cellular processes, but the detailed mechanisms, particularly in terms of regulation of AMPAR lateral movement, are not well understood. In the current study, using a single-molecule live imaging technique, we report that the overexpression of PKMζ in hippocampal neurons immobilized GluA2-containing AMPARs, highlighting a potential novel mechanism by which PKMζ may regulate memory and synaptic plasticity.
ISSN
1756-6606
Language
English
URI
https://hdl.handle.net/10371/138440
DOI
https://doi.org/10.1186/s13041-017-0334-7
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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