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Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jiyong | - |
dc.contributor.author | Kim, Hwan D. | - |
dc.contributor.author | Park, Jungha | - |
dc.contributor.author | Lee, Eun-seo | - |
dc.contributor.author | Kim, Eugene | - |
dc.contributor.author | Lee, Seunghun S. | - |
dc.contributor.author | Yang, Jin-Kyung | - |
dc.contributor.author | Lee, Yoon-Sik | - |
dc.contributor.author | Hwang, Nathaniel S. | - |
dc.date.accessioned | 2018-01-12T06:31:49Z | - |
dc.date.available | 2018-01-12T15:33:34Z | - |
dc.date.issued | 2018-01-02 | - |
dc.identifier.citation | Biomaterials Research, 22(1):1 | ko_KR |
dc.identifier.issn | 2055-7124 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138483 | - |
dc.description.abstract | Background
Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxide (GO) is considered as promising biomaterial due to its nontoxicity, high dispersity, and hydrophilic interaction, and these characteristics are key to stimulating the interactions between substrates and cells. Method In this study, GO substrates were fabricated via chemically immobilizing GO at 1.0mg/ml on glass slides. Furthermore, we examined the osteogenic responses of murine mesenchymal-like stem cells, C3H10T1/2 cells, on GO substrates. Results C3H10T1/2 cells on GO substrates resulted in increased cell surface area, enhanced cellular adhesions, and instigated osteogenic differentiation. Furthermore, priming of C3H10T1/2 cells with chondrocyte-conditioned medium (CM) could further induce a synergistic effect of osteogenesis on GO substrates. Conclusions All of these data suggest that GO substrate along with CM is suitable for upregulating osteogenic responses of mesenchymal stem cells. | ko_KR |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1E1A1A01943393, NRF-2017M3A9C6029699). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Graphene | ko_KR |
dc.subject | Osteogenesis | ko_KR |
dc.subject | Mesenchymal stem cells | ko_KR |
dc.subject | Graphene oxide | ko_KR |
dc.title | Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김지용 | - |
dc.contributor.AlternativeAuthor | 박정하 | - |
dc.contributor.AlternativeAuthor | 이은서 | - |
dc.contributor.AlternativeAuthor | 김유진 | - |
dc.contributor.AlternativeAuthor | 이승훈 | - |
dc.contributor.AlternativeAuthor | 양진경 | - |
dc.contributor.AlternativeAuthor | 이윤식 | - |
dc.identifier.doi | 10.1186/s40824-017-0112-8 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-01-07T04:15:37Z | - |
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