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CD34 stromal expression is inversely proportional to the extent of morphea
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Su | en |
dc.contributor.author | Park, Hyun-sun | - |
dc.contributor.author | Yoon, Hyun-Sun | - |
dc.contributor.author | Cho, Soyun | - |
dc.creator | 조소연 | - |
dc.date.accessioned | 2018-01-24T05:58:16Z | - |
dc.date.available | 2018-01-25T11:42:53Z | - |
dc.date.issued | 2017-10-22 | - |
dc.identifier.citation | 2017년 제69차 대한피부과학회 추계학술대회, pp. 349-350 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138847 | - |
dc.description.abstract | Background: Fibrosis is thought to be the main pathophysiology of scleroderma, and myofibroblasts play a main role in abnormal fibrotic pathologies. Altered distribution of dermal dendrocytes, particularly loss of CD34+ fibrocytes, has been reported in scleroderma. Objective: To investigate the relative expression and distribution of myofibroblast and CD34+ fibrocytes in morphea, we performed immunohistochemical stains using several relevant antibodies. Methods: Skin lesions of 50 patients with morphea and age-, sex- and site-matched normal skin of 50 subjects were evaluated for the following antibodies: SMA, CD34, CD31, and VCAM-1. Results: The patient group showed significantly higher expression of SMA and VCAM-1 stain than the control group (p=0.000 and p=0.027, respectively), while CD34 stromal stain was significantly decreased in the patient group (p=0.000). Within the patient group, CD34 stromal stain had an inverse correlation with SMA and VCAM-1 stains (r=-0.286, p=0.044, and r=-0.296, p=0.037, respectively). In subtype analysis, CD34 stromal expression was lost more in generalized morphea than non-generalized morphea. Limitations: Retrospective nature of the study. Conclusion: Mutually exclusive staining patterns of CD34 stromal and SMA stains suggest a phenotypic change of CD34+ fibrocytes into myofibroblasts with progression of disease in morphea. CD34 may be a useful marker in predicting the extent of morphea. | - |
dc.publisher | 대한피부과학회 | en |
dc.subject | CD34 stromal expression is inversely proportional to the extent of morphea | en |
dc.subject | 의약학 | en |
dc.subject | Scleroderma | - |
dc.subject | Morphea | - |
dc.subject | CD34 | - |
dc.subject | Smooth muscle actin | - |
dc.subject | Fibrocyte | - |
dc.title | CD34 stromal expression is inversely proportional to the extent of morphea | en |
dc.type | Conference Paper | - |
dc.contributor.AlternativeAuthor | 이지수 | - |
dc.contributor.AlternativeAuthor | 박현선 | - |
dc.contributor.AlternativeAuthor | 윤현선 | - |
dc.contributor.AlternativeAuthor | 조소연 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:A201716091 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200003 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079501 | - |
dc.description.srnd | CITE_RATE: | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:sycho@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN: | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | A201716091 | - |
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