S-Space College of Agriculture and Life Sciences (농업생명과학대학) Dept. of Agricultural Biotechnology (농생명공학부) Journal Papers (저널논문_농생명공학부)
Control of the gastrointestinal digestion of solid lipid nanoparticles using PEGylated emulsifiers
- Issue Date
- ELSEVIER SCI LTD
- Food Chemistry, Vol.239, pp. 442-452
- Control of the gastrointestinal digestion of solid lipid nanoparticles using PEGylated emulsifiers ; 자연과학 ; Solid lipid nanoparticle ; Polyethylene glycol ; Oral administration ; Gastrointestinal digestion ; Controllable digestion
- We prepared solid lipid nanoparticles (SLNs) with tristearin and various emulsifiers which had different chain length PEGs (10-100 times-repetition of ethylene glycol) to control their digestion fate in the gastrointestinal tract. Fabricated SLNs after acidic/high-ionic-strength media treatment were stable regardless of the f-potential (ZP) disappearance. Additionally, highly PEGylated SLNs successfully hindered the adsorption of both bile acid (BA) and lipase on the SLN surface, while lowly PEGylated SLNs interrupted that of only lipase. In simulated small intestinal fluid, lipolysis of highly PEGylated SLNs increased with decrease of the emulsifier density on the SLNs, whereas lipolysis of lowly PEGylated SLNs increased with decrease of the particle size. These results suggested that high PEGylation was more efficient than low PEGylation to hinder the lipolysis initiated from the competitive replacement of the SLN-covering emulsifiers with BAs. Consequently, the SLN digestion could be controlled by choosing the length and concentration of PEGylated emulsifiers. (C) 2017 Elsevier Ltd. All rights reserved.
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